Effectiveness of Vegan Diet and MyPlate Diet (Taiwanese Version) on Lipoproteins, Novel Markers of Cardiovascular Diseases, and Traditional Cardiometabolic Risk Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- lipoprotein particles size
研究概览
简要总结
Systematic inflammation and lipid profiles are two major therapeutic targets for cardiovascular diseases. The effectiveness of vegan diet has been reported (doi: 10.3389/fnut.2022.807810).
Aim:
To compare the effectiveness of a nutritionally balanced vegan diet and a Myplate diet ((Taiwanese version) on systematic inflammation and lipoprotein subclass.
Design: Randomized crossover design
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with dyslipidemia (at least one of the following)
- •TG ≥ 150 mg/dL
- •TC ≥ 200 mg/dL
- •LDL-c≥ 130 mg/dL,
- •HDL-c < 45 mg/dL for male or < 55 mg/dL for female or receiving statin treatment
排除标准
- •(fulfill one of the following condition):
- •chronic kidney disease
- •history of coronary artery disease
- •ischemic heart disease,
- •heart failure,
- •cancer of any type
结局指标
主要结局
lipoprotein particles size
时间窗: 12 weeks
lipoprotein particles size (nm)
Traditional cadiometabolic risk factors 2
时间窗: 12 weeks
HbA1c(%)
Novel inflammatory markers for cardiovascular disease and Lipoprotein particles concentration
时间窗: 12 weeks
GlycA (umol/L), lipoprotein particles concentration(umol/L)
Lipoprotein particles concentration
时间窗: 12 weeks
lipoprotein particles concentration (nmol/L）
Traditional cadiometabolic risk factors 1
时间窗: 12 weeks
TG(mg/dL), LDL-C(mg/dL), HDL-C(mg/dL), Total cholesterol(mg/dL)
Trimethylamine-N-oxide
时间窗: 12 weeks
TMAO (uM). TMAO is a low molecular weight compound that belongs to the class of amine oxides
Traditional cadiometabolic risk factors 3
时间窗: 12 weeks
HOMA-IR index (Homeostasis Model Assessment-Insulin Resistance index)
次要结局
未报告次要终点