Study of the Effects of Docosahexaneoic Acid (DHA) on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Test migration ability by video microscopy
研究概览
简要总结
Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing trabulectomy or deep sclerectomy
- •Patients informed about the study
排除标准
- •Patients who refuse to take part in the study
结局指标
主要结局
Test migration ability by video microscopy
时间窗: At baseline
Test of cell viability by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide)
时间窗: At baseline
Test proliferation with immunohistochemistry (Ki67 staining)
时间窗: At baseline
Analysis of cell cycle in flow cytometry
时间窗: At baseline
次要结局
未报告次要终点