Immunoglobulin G Antibody Immune Response Profile Following Infection With SARS-CoV-2 in COVID-19 Egyptian Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- rising titre of IGg antibodies
研究概览
简要总结
The objective of this study is to detect the evidence on the immune response following acute SARS-CoV-2 infections. the study will report the profile of IgG specific antibodies levels to SARS-CoV-2 infection found in recovered coronavirus disease (COVID-19) patients after infection for both symptomatic and asymptomatic patients.
详细描述
A total of 30 COVID-19 patients for the study will be enrolled. All the patients enrolled were confirmed to be infected with SARS-CoV-2 by RT-PCR assay for nasal and pharyngeal swab specimens.
For the study, serum samples of the 30 patients will be collected and will be investigated for the detection rate for immunoglobulin G (IgG). The first sample will be collected 2 weeks after the second negative RT-PCR assay for nasal and pharyngeal swab specimens and 6 samples will be collected after that for 6 months later; one serum sample tested every month for 6 months after.
The following questions will be addressed:-
- What proportion of confirmed cases develops specific IgG antibodies to SARS-CoV-2?
- How long is the duration of detection of serum IgG antibodies and antibody titres over time following infection with SARS-CoV-2?
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with recent COVID- 19 infection(2 weeks after the second negative RT-PCR assay)
排除标准
- •patients on immune-suppressive therapy
- •patients with immunological disease
结局指标
主要结局
rising titre of IGg antibodies
时间窗: first month
it's expected to have COVID-19 antibodies within 1month of infection the antibody titre expected to rise the fall to a lower levels
次要结局
未报告次要终点
研究者
Asmaa Mohamed Goda
assistant professor of medical microbiology and immunology at sohag faculty of medicine fa
Sohag University