Neurophysiological Study of tDCS Effects in Healthy Volunteers
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Neurophysiological mesures changes
研究概览
简要总结
Transcranial direct current stimulation is a tool to modulate cortical excitability.
详细描述
Anodal transcranial direct currenti stimulation over visual cortex is able to decrease the thermo-nociceptive sensibility and thermonociceptive potentials, whilst cathodal transcranial direct current stimulation has the opposite effect, it decreases VEP amplitude and habituation. This neuromodulation technique is probably a tool in the prevention in episodic and chronic migraine.
The aim of the study is to study short and long term effect of tDCS over pain treshold, contact heat evoked potentials, blink reflex and visual evoked potentials in healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
排除标准
- •age below 18 or above 65 years
- •personal history of recurrent headache or other neurological diseases especially seizures,
- •familial history of recurrent headache
- •child migraine equivalents (motion sickness, cyclic vomiting or recurrent abdominal pain, somnambulism etc.. . .)
- •chronic pain syndromes
- •analgesics intake at the time of recording
- •contra-indications to tDCS neurostimulation (metal prosthetics in the head or internal stimulation like a pacemaker).
研究组 & 干预措施
Cefaly tDCS
Cathodal Cefaly tDCS is delivered over the visual cortex at 2 mA of intensity, for 20 minutes, for 5 consecutive days in 9 HV. The anode is placed over the left DLPFC.
2 mA anodal tDCS is delivered over the visual cortex, for 20 minutes, for 5 consecutive days in 9 HV
干预措施: Cefaly tDCS (Device)
结局指标
主要结局
Neurophysiological mesures changes
时间窗: up to 1 month
Modifications in neurophysiological test after direct current stimulation
次要结局
未报告次要终点
研究者
Jean Schoenen
Honorary Full Professor
University of Liege