NCT04136457已完成不适用
Proteome Remodelling and Dynamics in Human Skeletal Muscle: Effect of Training
Morten Hostrup, PhD1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2019年10月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Skeletal muscle proteome signature
研究概览
简要总结
The purpose of the project is to investigate the proteome signature dynamics and remodelling in human skeletal muscle induced by exercise training
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •VO2max > 55 mL/min/kgLM for men and > 50 for women (only applicable for endurance and sprint training interventions)
- •BMI < 26
排除标准
- •Chronic disease deemed by the medical doctor to pose a risk or to affect study outcomes
- •Use of prescription medicine deemed by the medical to affect study outcomes
- •Pregnancy
结局指标
主要结局
Skeletal muscle proteome signature
时间窗: Change from baseline at week 6 or 8 depending on the intervention
Pathway enrichment analysis of the muscle proteome
Anabolic signaling
时间窗: Change in anabolic signaling from rest to 1 hour following resistance exercise both at baseline and following 8 weeks of resistance training
Western blotting of proteins related to anabolic signaling
次要结局
- Maximal oxygen consumption(Change from baseline at week 6 following endurance and sprint training)
- Satellite cells(Change from baseline at week 8 following resistance training)
- Skeletal muscle mitochondrial respiration(Change from baseline at week 6 following endurance and sprint training)
- Myonuclei(Change from baseline at week 8 following resistance training)
- Fiber size(Change from baseline at week 8 following resistance training)
- Body composition(Change from baseline at week 6 or 8 depending on the intervention)
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen
研究点 (1)
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