NL-OMON23943尚未招募不适用
A prospective, randomized, double-blind, placebo-controlled study to assess the effects of oral beta-alanine supplementation on exercise performance and muscle carnosine in patients with COPD.
Radboudumc Board of Directors0 个研究点目标入组 154 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 154
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •COPD, GOLD group B or D
- •- Modified Medical Research Council (mMRC) dyspnoea score =2
- •- Clinically stable according to the pulmonary physician, i.e. no exacerbation and/or hospitalization within the previous 4 weeks.
- •- Age between 40-80 years
- •- Attending the regular in- or outpatient pulmonary rehabilitation program in Dekkerswald or CIRO and receiving NPLE
排除标准
- •Patients will be excluded if they meet at least one of the following criteria: instable cardiac disease, use of anabolic steroids during PR program, history of drugs/alcohol abuse, vegetarianism, inability to understand the Dutch language, self-reported beta-alanine supplementation in the past 3 months, participation in a PR program within the past 12 months, inability to perform an incremental shuttle walk test.
- •If the patient agrees to undergo a vastus lateralis muscle biopsy, the following exclusion criterion will also apply: bleeding disorder, a recent trauma of the muscle, or an infection in the region of the proposed biopsy.
研究者
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