Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
研究概览
简要总结
The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.
详细描述
To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery
排除标准
- •No Selective Dorsal Rhizotomy surgery
研究组 & 干预措施
3Tesla MRI with DTI-MRI and rsfcMRI
Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months.
干预措施: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia (Procedure)
结局指标
主要结局
Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
时间窗: Baseline and 12 months
This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR).
Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
时间窗: Baseline and 12 months
This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR).
Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
时间窗: Baseline and 12 months
This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)
Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
时间窗: Baseline and 12 months
This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)
次要结局
未报告次要终点
研究者
Manish Narendra Shah
Assistant Professor
The University of Texas Health Science Center, Houston