NCT00977717已完成不适用
Pharmacogenomic Study to Predict Toxicity and Response in Colorectal Cancer Patients Treated With Oxaliplatin-based Chemotherapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- neuropathy
研究概览
简要总结
In order to explore genetic factors that may determine the neurotoxicity of oxaliplatin-based chemotherapy, germinal gene polymorphisms will be analyzed.
详细描述
To investigate the impact of single nucleotide (SNP) polymorphism on the toxicity profile in colorectal cancer patients treated with FOLFOX chemotherapy, 10 cc of blood will be drawn in EDTA tube for extraction. DNA will be extracted from peripheral blood samples using DNA isolation kit, and SNP polymorphisms will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 18 or older
- •curatively resected colon adenocarcinoma
- •pathologically staged III
- •adequate performance status
- •adequate major organ functions
- •to be treated with adjuvant FOLFOX chemotherapy
- •written informed consent
排除标准
- •those who disagree the study
结局指标
主要结局
neuropathy
时间窗: six months
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Long Term Effect of Oxaliplatin Treatment in Cancer SurvivorsColorectal Cancer SurvivorsOxaliplatin RegimenAdultNCT02970526University Hospital, Clermont-Ferrand409
已完成
不适用
Pharmacogenomic Study (Adjuvant Chemotherapy)Gastric CancerNCT01470404Samsung Medical Center792
已完成
不适用
Evaluation for neurotoxicity of oxaliplatin using Nerve Conduction Velocitycolorectal cancerJPRN-UMIN000004305Oita University, Faculty of Medecine30
已完成
2 期
Pegylated Recombinant Human Arginase 1 in Combination With Oxaliplatin and Capecitabine for the Treatment of HCCHepatocellular CarcinomaNCT02089633Bio-Cancer Treatment International Limited17
已完成
2 期
Oxaliplatin-Based Chemotherapy and Chemoradiotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal CarcinomaGastroesophageal CancerEsophageal CancerNCT00525915M.D. Anderson Cancer Center126