NCT00293696已完成4 期
A Randomised Pilot Study to Evaluate the Effect(s) of Casodex 150 mg and Zoladex 3.6 mg on Pathological and Genomic Tumour Markers in Subjects Undergoing Radical Prostatectomy for Localised Prostate Carcinoma
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Proliferation by Ki67,
研究概览
简要总结
To evaluate anti-androgen (bicalutamide) induced biological and molecular changes in prostate comparison to chemical castration induced (goserelin) ones
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed localised prostate biopsy specimen that contains sufficient tumour for evaluation of cell proliferation and apoptosis markers
- •Patients who are scheduled for radical prostatectomy with curative intents
排除标准
- 未提供
结局指标
主要结局
Proliferation by Ki67,
apoptosis marker (TUNEL assay),
Gleason score
次要结局
- expression of known androgen-regulated genes,
- biomarkers of apoptotic pathway,
- (novel) genomic transcripts
研究者
研究点 (2)
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