NCT01058538已完成1 期
A Dose Finding Pharmacokinetic Study of the Tumour-targeting Human L19IL2 Monoclonal Antibody-Cytokine Fusion Protein in Patients With Advanced Solid Tumours
Philogen S.p.A.2 个研究点 分布在 2 个国家目标入组 33 人开始时间: 2005年11月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- To determine the maximum tolerated dose (MTD) and recommended dose (RD) of the human L19IL2 fusion-cytokine.
研究概览
简要总结
This is a Phase I/II study for patients with solid tumors and renal cell carcinoma (RCC; for the Phase II part). L19-IL2 is a tumor targeted immunocytokine constituted of a single chain Fragment variable (scFv) format directed against the ED-B domain of fibronectin, one of the most important markers for neoangiogenesis, and the human cytokine interleukin-2 (IL2).
详细描述
This is an open-label, non-randomised, multicentre, Phase I/II study to assess safety, pharmacokinetics (PK), and early signs of activity of L19-IL2 monotherapy.
In the first part of the study, there will be 5 dose escalation steps in sequential cohorts of patients with advanced solid tumours. In the second part of the study, patients with advanced RCC will be given a fixed dose of L19IL2 at the RD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For the first part of the study: histologically or cytologically confirmed solid cancer with evidence of advanced disease for which no other standard treatment is available or appropriate. For the second part of the study: Histologically or cytologically confirmed advanced RCC.
- •Patients must have at least one measurable lesion as detected by computed tomography (CT).
- •All acute toxic effects (excluding alopecia) of any prior therapy must have resolved to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) (v3.0) Grade </=
- •Patients who have received autologous marrow/stem cell infusion using monoclonal antibody-purged specimens are eligible.
- •Adult patients of both sexes aged 18 years or older.
- •Eastern Cooperative Oncology Group (ECOG) performance status </=
- •Sufficient haematological, liver and renal function:
- •Absolute neutrophil count (ANC) >/=1.5 x 109/L, platelets >/=100 x 109/L, haemoglobin (Hb) >/=9.0 g/dL,
- •Alkaline phosphatase (AP) </=3 x upper limit of the reference range (ULN) and alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) </=3 x ULN, and bilirubin <1.5 x ULN; however, in the presence of liver metastases, AP </=5 x ULN and ALT and/or AST </=5 x ULN, and bilirubin <1.5 x ULN,
- •Creatinine </=ULN, or 24 h creatinine clearance >/=50 mL/min.
- •Pulse oximetry >94% on room air.
- •Negative serum pregnancy test for females of childbearing potential within 14 days of starting treatment.
- •Life expectancy of at least 3 months.
- •Evidence of a personally signed and dated informed consent indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the study.
- •Willingness and ability to comply with the scheduled visits, treatment plan, laboratory tests and other study procedures.
- •Negative human immunodeficiency virus (HIV) test 2 to 3 weeks before administration of study treatment (with informed consent for test taken).
排除标准
- •Presence of active infections (eg requiring antibiotic therapy) or other severe concurrent disease, which, in the opinion of the investigator, would place the patient at undue risk or interfere with the study.
- •Presence of known brain metastases.
- •Chronic aggressive hepatitis or active autoimmune diseases.
- •History within the last year of acute or subacute coronary syndromes including myocardial infarction, unstable or severe stable angina pectoris.
- •Heart insufficiency (>Grade II New York Heart Association [NYHA] criteria).
- •Irreversible cardiac arrhythmias requiring permanent medication.
- •Uncontrolled hypertension.
- •Ischaemic peripheral vascular disease (Grade IIb-IV).
- •Severe rheumatoid arthritis.
- •Severe diabetic retinopathy.
- •Recovery from major trauma including surgery within 4 weeks of administration of study treatment.
- •Known history of allergy to intravenously administered proteins/peptides/antibodies.
- •Pregnancy or breast feeding. Female patients must agree to use effective contraception, or be surgically sterile or postmenopausal. The definition of effective contraception will be based on the judgement of the principal investigator or a designated associate.
- •Chemotherapy (standard or experimental) within 4 weeks of the administration of study treatment, or 6 weeks for nitrous ureas, l-phenylalanine mustard (LPAM) or temozolamide.
- •Radiation therapy within 4 weeks of the administration of study treatment.
- •Previous in vivo exposure to monoclonal antibodies for biological therapy in the 6 weeks before administration of study treatment.
- •Growth factors or immunomodulatory agents within 7 days of the administration of study treatment.
- •Prior allografts (including bone marrow or stem cells).
- •Patient requires or is taking corticosteroids or other immunosuppressant drugs on a long term basis. Limited use of corticosteroids to treat or prevent acute hypersensitivity reactions is not considered an exclusion criterion.
- •Investigational study drug taken within 4 weeks of the administration of study treatment or concurrent treatment with other anti-cancer therapy.
研究组 & 干预措施
L19IL2
Experimental
干预措施: L19IL2 (Drug)
结局指标
主要结局
To determine the maximum tolerated dose (MTD) and recommended dose (RD) of the human L19IL2 fusion-cytokine.
时间窗: 21 days
次要结局
- To determine the qualitative and quantitative toxicity profile.(21 days)
- To assess the presence of anti-fusion protein antibodies in treated patients.(18 weeks)
- To determine the pharmacokinetic profile.(5 days)
- To evaluate the safety profile of repeated administrations of L19IL2 in patients treated at the RD.(1 year)
- To identify early signs of antitumour activity.(1 year)
研究者
研究点 (2)
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