Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Language production
研究概览
简要总结
The purpose of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on language production.
详细描述
Background:
Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).
Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.
Aim and procedure:
The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •L1 French, knowledge of English as a foreign language
- •18-45 years of age
- •Right-handedness
排除标准
- •epilepsy /family history of epilepsy
- •brain surgery, traumatic brain injuries
- •cardiac pacemaker, metallic objects in the body
- •history of neurological diseases or psychiatric disorders
- •drug use (alcohol, psychoactive medication)
- •developmental language disorder
研究组 & 干预措施
rTMS
干预措施: rTMS (Device)
Sham rTMS
干预措施: Sham rTMS (Device)
结局指标
主要结局
Language production
时间窗: within 30 mins after rTMS/sham rTMS
Picture naming task and word translation task
次要结局
- non-verbal executive functions task(within 30 mins after rTMS/sham rTMS)
研究者
Jean-Marie Annoni
Prof. Dr. med.
University of Fribourg
