Taste Physiology in Healthy, Normal-weight Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI)
研究概览
简要总结
Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •right-handed healthy males
- •Body-mass index of < 25
- •Age 18-45 years
- •non-smoking
排除标准
- •Substance abuse
- •Regular intake of medications (except for oral contraceptives)
- •Medical or psychiatric illness, especially: diabetes, pace-maker, claustrophobia
- •History of gastrointestinal disorders
- •Food allergies, glutamate intolerance
- •Body piercings that cannot be removed
研究组 & 干预措施
200 mL tap water
Single intragastric instillation of 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 200 mL tap water via nasogastric tube (Dietary Supplement)
2 g citric acid
Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube (Dietary Supplement)
2 g salt
Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube (Dietary Supplement)
0.017 g quinine
Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube (Dietary Supplement)
1 g monosodium glutamate
Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube (Dietary Supplement)
25 g glucose
Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube
干预措施: Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube (Dietary Supplement)
结局指标
主要结局
regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI)
时间窗: changes from baseline to one hour after treatment
Changes in resting state functional connectivity
次要结局
- gastrointestinal satiation peptide secretion(changes from baseline to one hour after treatment)
- glucose and insulin secretion(changes from baseline to one hour after treatment)