Organochlorine Concentration in Adipose Tissue and Pancreatic Adenocarcinoma : a Case Control Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Adipose tissue organochlorine concentration
研究概览
简要总结
Pancreatic adenocarcinoma represents more than 90% of pancreatic neoplasms. Around 14000 new cases of pancreatic adenocarcinoma are being diagnosed each year in France and about 8.6% in Grand Est region. National incidence has doubled for men and tripled for women between 1982 and 2012. Pancreatic adenocarcinoma is the deadliest digestive cancer, with only 7 to 8% all stages 5-year survival. It will become the second deadliest in Europe, behind bronchopulmonary cancer.
Several risk factors have been identified such as diabetes, tobacco, chronic pancreatitis or obesity. However, a mismatch exists between incidence forecasts and actual risk factors knowledge. Several hypothesis plead for an environnemental cause.
Plant protection products oncogenetic effects are known and have been proved to be responsible for tumors, including haematological malignancies. Its role in pancreatic carcinogenesis is still poorly studied and show heterogeneous results. They do not allow to conclude for causality. Organochlorines is a specific subset of plant protection product that store in lipids during lifetime.
The aim is to study association between organochlorine concentration in adipose tissue with pancreatic adenocarcinoma.
详细描述
Unicentric prospective case control study comparing organochlorine levels including patients diagnosed with a pancreatic adenocarcinoma undergoing a surgery allowing to collect an adipose tissue sample (10g).
Controls are adults with no pancreatic cancer (excluded by a 6 months old computed tomography excluding the probability of a pancreatic neoplasm), paired with cases upon age and body mass index, with a scheduled surgical procedure allowing to collect an adipose tissue sample without extending procedure length.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed with a pancreatic adenocarcinoma, all stages allowed
- •undergoing a surgery allowing to take a 10 grams adipose tissue sample
- •patients without a pancreatic neoplasm on a 6 months old CT scan before inclusion
- •undergoing a surgery allowing to take a 10 grams adipose tissue sample
排除标准
- •patients diagnosed with a pancreatic adenocarcinoma developed on IPMN or cystadenoma
- •patient with a known genetic predisposition increasing pancreatic adenocarcinoma risk
- •histopathology proof of a mixed neuroendocrine neoplasm
- •no surgery allowing to take a 10 grams adipose tissue sample
- •patients with a pancreatic neoplasm on a 6 months old CT scan before inclusion
- •no surgery allowing to take a 10 grams adipose tissue sample
结局指标
主要结局
Adipose tissue organochlorine concentration
时间窗: Day 0
QuEChERS method to extract organochlorines Use of Agilent 7010 Detection limit : 10ng/g of adipose tissue
次要结局
- Urine organochlorine concentration(Day 0)