Heterozygous Individuals for AGXT and Kidney Stones
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Urinary Oxalate Excretion
研究概览
简要总结
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 18 years of age
- •history of calcium oxalate stones
- •heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel
- •willingness to comply with a controlled diet for five days
排除标准
- •pregnant individuals
- •individuals who are currently breast feeding
研究组 & 干预措施
Controlled Dietary Study
Participants will consume the controlled diet for five days. Participants will provide urine and blood samples to measure oxalate levels.
干预措施: Controlled Diet (Other)
结局指标
主要结局
Urinary Oxalate Excretion
时间窗: Baseline through Day 6
Urinary oxalate excretion from urine samples will be measured as mg/day
Urinary Oxalate Excretion
时间窗: Baseline through Day 4
Urinary oxalate excretion from urine samples will be measured as mg/day
次要结局
未报告次要终点
研究者
Kyle D. Wood
Principal Investigator
University of Alabama at Birmingham