NCT02037412终止4 期
Impact of Ticagrelor on the Endothelial Healing Following Drug-eluting Stent Implantation in the Patients With Acute Coronary Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Stent re-endothelialization
研究概览
简要总结
The investigators hypothesized that ticagrelor may enhance endothelial healing after DES implantation by increasing adenosine concentrations by the inhibition of adenosine uptake into erythrocytes, compared to clopidogrel. Thus, the investigators will evaluate the extent of endothelialization (stent strut coverage) and neointimal hyperplasia (neointimal thickness) 3 months after DES implantation by optical coherence tomography (OCT)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients ≥ 20 years old
- •Patients who are hospitalized and expected to undergo PCI for acute coronary syndrome, including acute myocardial infarction and unstable angina.
排除标准
- •Age > 80 years
- •Cardiogenic shock or unstable patients
- •Increased risk of bleeding, anemia, thrombocytopenia
- •A need for oral anticoagulation therapy
- •Pregnant women or women with potential childbearing
- •Life expectancy < 1 year
研究组 & 干预措施
Ticagrelor Arm
Experimental
Ticagrelor Arm
干预措施: Ticagrelor (Drug)
Clopidogrel Arm
Active Comparator
Clopidogrel Arm
干预措施: Clopidogrel (Drug)
结局指标
主要结局
Stent re-endothelialization
时间窗: Three months after stent implantation
Percentage of stent coverage measured by OCT
Neointimal hyperplasia
时间窗: Three months after stent implantation
Neointimal thickness measured by OCT
次要结局
未报告次要终点
研究者
研究点 (1)
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