JPRN-jRCT2041230069招募中3 期
A PHASE 3 OPEN-LABEL STUDY OF PTC923 (SEPIAPTERIN) IN PHENYLKETONURIA
KOBAYASHI Tomoyo0 个研究点目标入组 15 人开始时间: 2023年8月12日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- ot applicable 至 ot applicable（—）
- 性别
- All
入选标准
- •1.Clinical diagnosis of PKU with hyperphenylalaninemia (HPA) documented by past medical history of at least 2 blood Phe measurements >=600 micro-mol/L.
- •2.Women of childbearing potential must have a negative pregnancy test at screening and agree to abstinence or the use of at least one highly effective form of contraception for the duration of the study, and for up to 90 days after the last dose of the study drug.
- •3.Males who are sexually active with women of childbearing potential who have not had a vasectomy must agree to use a barrier method of birth control during the study and for up to 90 days after the last dose of study drug. Males must also refrain from sperm donations during this time period.
- •4.Willing to continue current diet unchanged while participating in the study (unless specifically instructed to change diet during the study by the investigator).
排除标准
- •1.Inability to tolerate oral medication.
- •2.A female who is pregnant or breastfeeding, or considering pregnancy.
- •3.Serious neuropsychiatric illness (for example, major depression) not currently under medical control, that in the opinion of the investigator or sponsor, would interfere with the participant's ability to participate in the study or increase the risk of participation for that participant.
- •4.Past medical history and/or evidence of renal impairment and/or condition including moderate/severe renal insufficiency (glomerular filtration rate [GFR] <60 milliliters [mL]/minute [min] min as estimated most recently during qualifying participation in a feeder study) and/or under care of a nephrologist.
- •5.Any other condition that in the opinion of the investigator or sponsor, would interfere with the participant's ability to participate in the study or increase the risk of participation for that participant.
- •6.Requirement for concomitant treatment with any drug known to inhibit folate synthesis (for example, methotrexate).
- •7.Concomitant treatment with tetrahydrobiopterin (BH4) supplementation (for example, sapropterin dihydrochloride, KUVAN) or pegvaliase-pqpz (PALYNZIQ).
- •Additional criteria for non-feeder participants who did not participate in a feeder study:
- •8.Gastrointestinal disease (such as irritable bowel syndrome, inflammatory bowel disease, chronic gastritis, and peptic ulcer disease, etc) that could affect the absorption of study drug.
- •9.History of gastric surgery, including Roux-en-Y gastric bypass surgery or an antrectomy with vagotomy, or gastrectomy.
- •10.History of allergies or adverse reactions to synthetic BH4 or sepiapterin.
- •11.Any clinically significant laboratory abnormality as determined by the investigator.
- •12.Any abnormal physical examination and/or laboratory findings indicative of signs or symptoms of renal disease, including calculated GFR <60 milliliters (mL)/minute/1.73 square meter (m^2).
- •13.Confirmed diagnosis of a primary BH4 deficiency as evidenced by biallelic pathogenic mutations in 6-pyruvoyltetrahydropterin synthase, recessive GTP cyclohydrolase I, sepiapterin reductase, quinoid dihydropteridine reductase, or pterin-4-alphacarbinolamine dehydratase genes.
研究者
相似试验
进行中（未招募）
1 期
A Phase 3 Study of PTC923 (SEPIAPTERIN) in Subjects with PhenylketonuriaMetabolic Disorders - PhenylketonuriaMedDRA version: 20.0Level: LLTClassification code 10034873Term: Phenylketonuria (PKU)System Organ Class: 100000004850EUCTR2021-000497-28-DKPTC Therapeutics, Inc.200
招募中
1 期
A Phase 3 Open-Label Study of PTC923 (Sepiapterin) in PhenylketonuriaMetabolic Disorders - PhenylketonuriaMedDRA version: 20.0Level: LLTClassification code: 10034873Term: Phenylketonuria (PKU) Class: 10010331CTIS2023-509229-31-00PTC Therapeutics Inc.200
进行中（未招募）
1 期
A Phase 3 Study of PTC923 (Sepiapterin) in Subjects with PhenylketonuriaMetabolic Disorders - PhenylketonuriaMedDRA version: 20.0Level: LLTClassification code 10034873Term: Phenylketonuria (PKU)System Organ Class: 100000004850EUCTR2021-000497-28-DEPTC Therapeutics, Inc.200
尚未招募
3 期
A phase 3 open-label study of PTC923 (Sepiapterin) in Phenylketonuriahyperphenylalaninemia10037008PhenylketonuriaNL-OMON53510PTC Therapeutics Inc.8
进行中（未招募）
1 期
A Phase 3 Extension Study of PTC923 in Subjects with PhenylketonuriaMetabolic Disorders - PhenylketonuriaMedDRA version: 20.0Level: LLTClassification code 10034873Term: Phenylketonuria (PKU)System Organ Class: 100000004850EUCTR2021-000497-28-NLPTC Therapeutics, Inc.200