NCT01833338终止不适用
Coronary Artery Plaque Characterisation With Non-invasive Multi-Slice Computed Tomography and Invasive Intravascular Ultrasound and Optical Coherence Tomography in Patients With Acute Coronary Syndromes Without ST-segment Elevation
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Accuracy of detection of thrombus with MSCT as compared to IVUS and OCT will be investigated.
研究概览
简要总结
The accuracy of coronary plaque characterization with Multi-slice computed tomography as compared to intravascular ultrasound and optical coherence tomography will be investigated in patients presenting with acute coronary syndrome without ST-elevation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chest pain suggestive for myocardial ischemia for at least 30 minutes; - Electrocardiogram (ECG) with ST-segment shifts (ST-segment depression >1 mm in at least two contiguous leads or transient ST-segment elevation > 1mm with duration of < 30 min in at least two contiguous leads) and/or T-wave changes (T-wave inversion > 1.5 mm in at least three contiguous leads); - Positive hs Troponin T > 14 ng/L or positive Troponin T <0.01 µg/L - Clinical indication for invasive coronary angiography followed by PCI of the ischemia-related target lesion; - Informed consent.
排除标准
- •Persistent ST-elevation of >1 mm in 2 or more leads; - Need for emergency invasive coronary angiography and percutaneous coronary intervention (PCI); - Need for emergency coronary artery bypass grafting; - Presence of cardiogenic shock; - Estimated glomerular filtration rate (eGFR) < 50 ml/min; - Known allergy to iodine contrast agents; - Cardiac rhythms other than sinus rhythm; - Inability to lay supine; - Inability tot sustain a breath-hold for 15 seconds; - Inability to provide informed consent.
研究组 & 干预措施
Single arm
Other
There is only one arm in this study. All patients undergo MSCT, IVUS and OCT.
干预措施: Imaging (Device)
结局指标
主要结局
Accuracy of detection of thrombus with MSCT as compared to IVUS and OCT will be investigated.
时间窗: 24 hours
All imaging methods will be performed in each patient. A 24 hour period is the maximum allowed time gap between MSCT and invasive imaging (OCT/IVUS).
次要结局
- Accuracy of atherosclerotic plaque characterisation with MSCT as compared to IVUS and OCT will be investigated.(24 hours)
研究者
Gabija Pundziute
Principal Investigator
University Medical Center Groningen
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Comparison of Coronary Computed Tomography Angiography-Derived vs Invasive Fractional Flow Reserve Assessment in Patients with Severe Aortic Valve Stenosiscoronary artery disease with severe aortic valve stenosisJPRN-UMIN000039395Department of Cardiology, Shonan Kamakura General Hospital120
已完成
不适用
Multislice computed tomography coronary angiography in patients with stable and unstable angina: a multicenter study.NL-OMON20510ZonMw320
已完成
不适用
Computed Tomography and Coronary Plaque StudyCoronary Artery DiseaseJPRN-UMIN000001581Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University1,000
尚未招募
不适用
Advanced Coronary Plaque Morphology Assessment Using Photon-counting Detection and Invasive Coronary ImagingCoronary DiseaseStent RestenosisCoronary Artery DiseasePCINCT06499207Medical University of Vienna25
已完成
不适用
Multislice Spiral Computed Tomography and CardiomyopathyCardiomyopathiesNCT00305916Rennes University Hospital60