NCT02898961已完成4 期
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Centre Hospitalier Universitaire de Nīmes1 个研究点 分布在 1 个国家目标入组 63 人开始时间: 2014年10月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Presence/absence of target peak serum concentration of aminosides
研究概览
简要总结
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patient with severe sepsis
- •Treated with aminoglycosides
排除标准
- •Renal replacement therapy
- •Allergy to aminoglycosides
- •Confirmed and/or suspected to have myasthenia
- •ICU-acquired neuromuscular disorder
- •Under guardianship
- •Prisoners
- •The patient has already participated in the present protocol
研究组 & 干预措施
The study population
Experimental
ICU patients with severe sepsis treated with aminoglycosides were recruited.
Intervention: 30 mg/kg amikacin or 8 mg/kg gentamicin
干预措施: 30 mg/kg amikacin or 8 mg/kg gentamicin (Drug)
结局指标
主要结局
Presence/absence of target peak serum concentration of aminosides
时间窗: 30 minutes after the end of the infusion.
Achievement of targeted peak serum concentration?
次要结局
未报告次要终点
研究者
研究点 (1)
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