Prevalence of Hyperparathyroidism Among End-Stage Renal Disease Patients on Regular Hemodialysis and Its Relation to Dialysis Adequacy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 130
- 主要终点
- Prevalence of secondary hyperparathyroidism
研究概览
简要总结
This cross-sectional study aims to determine the prevalence of secondary hyperparathyroidism among end-stage renal disease patients on regular hemodialysis and to evaluate its relationship with dialysis adequacy at Assiut University Hospitals.
详细描述
Secondary hyperparathyroidism is a common complication of end-stage renal disease and is associated with bone disease, vascular calcification, and increased mortality. Dialysis adequacy, measured by spKt/V and urea reduction ratio (URR), may influence phosphate control and parathyroid hormone levels.
This observational cross-sectional study will include adult patients with end-stage renal disease maintained on regular thrice-weekly hemodialysis for at least three months. Dialysis adequacy will be assessed by spKt/V and URR. Serum intact parathyroid hormone (iPTH) and mineral parameters will be measured.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 18 years or older
- •Diagnosed with end-stage renal disease
- •Maintained on regular thrice-weekly hemodialysis for at least three consecutive months
- •Written informed consent
排除标准
- •- Primary hyperparathyroidism or prior parathyroidectomy
- •Active severe infections or acute systemic illnesses
- •Active malignancy
- •Severe hepatic dysfunction or chronic liver cirrhosis
研究组 & 干预措施
Single cohort: ESRD patients on regular hemodialysis
Adult patients with end-stage renal disease on regular thrice-weekly hemodialysis who will undergo assessment of dialysis adequacy (spKt/V and URR) and measurement of serum intact parathyroid hormone and mineral parameters.
结局指标
主要结局
Prevalence of secondary hyperparathyroidism
时间窗: Baseline
Proportion of patients with elevated intact parathyroid hormone (iPTH) levels above the target range (greater than 9 times the upper limit of normal) among regular hemodialysis patients.
次要结局
- Prevalence of adequate dialysis(Baseline)
- Correlation between dialysis adequacy and iPTH level(Baseline)
- Serum phosphate levels according to dialysis adequacy(Baseline)
- Serum calcium level(Baseline)
- Serum phosphate level(Baseline)
- Serum alkaline phosphatase level(Baseline)
- Calcium-phosphorus product(Baseline)
研究者
Lamia Abdallah fathey
Resident Physician
Assiut University