Real-World Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten - a Single-Center Descriptive Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 163
- 试验地点
- 1
- 主要终点
- Participant age
研究概览
简要总结
The purpose of this study is to evaluate the real-world outcomes of individuals diagnosed with obstructive hypertrophic cardiomyopathy (oHCM) treated with mavacamten at the Hospital of The University of Pennsylvania in the US
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years at index date
- •Prescription of mavacamten for the treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM)
- •≥ 4 weeks of follow-up after prescription of mavacamten
排除标准
- •Data collection as part of a clinical trial during the study period
- •Current participation in a myosin inhibitor clinical trial
研究组 & 干预措施
Participants prescribed mavacamten treatment
干预措施: Mavacamten (Drug)
结局指标
主要结局
Participant age
时间窗: Baseline
Participant gender
时间窗: Baseline
Participant race
时间窗: Baseline
Participant ethnicity
时间窗: Baseline
Participant insurance coverage
时间窗: Baseline
Participant heart rate
时间窗: Baseline
Participant genotype
时间窗: Baseline
Participant family history
时间窗: Baseline
Participant echocardiogram measurements
时间窗: Baseline
Participant comorbidities
时间窗: Baseline
Mavacamten index dose prescribed
时间窗: Baseline
Participant Body Mass Index
时间窗: Baseline
Participant blood pressure
时间窗: Baseline
Participant New York Heart Association (NYHA) functional class
时间窗: Baseline, and at weeks 4, 8, 12, 24, 36, 48, 60, 72, 84, 96, and 108 weeks
Participant echocardiogram measurements: Left ventricular outflow tract (LVOT) gradient results at rest, Valsalva and post-exercise (if available)
时间窗: Baseline, and at weeks 4, 8, 12, 24, 36, 48, 60, 72, 84, 96, and 108 weeks
Participant echocardiogram measurements: Left ventricular ejection fraction (LVEF) percentage
时间窗: Baseline, and at weeks 4, 8, 12, 24, 36, 48, 60, 72, 84, 96, and 108 weeks
Participant echocardiogram measurements: Maximum left ventricular wall thickness
时间窗: Baseline, and at weeks 4, 8, 12, 24, 36, 48, 60, 72, 84, 96, and 108 weeks
Participant New York Functional Class classification
时间窗: Baseline
Participant hypertrophic cardiomyopathy (HCM) treatment history
时间窗: Baseline
Participant obstructive hypertrophic cardiomyopathy (oHCM) symptoms (syncope, shortness of breath, fatigue, exercise intolerance, palpitations)
时间窗: Baseline
次要结局
未报告次要终点