Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Prognosis
研究概览
简要总结
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.
详细描述
The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.
On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient voluntarily signs an informed consent form;
- •Adult patients who meet the criteria for heat stroke;
- •Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.
排除标准
- •Age <18 years old or >90 years old;
- •Patients with advanced tumors, Pregnancy or lactation;
- •Patients who missed out during treatment and whose data are incomplete.
结局指标
主要结局
Prognosis
时间窗: Day 30 and Day 90
Rate of Surviving or Died Participants with Heat Stroke
次要结局
- Heat Stroke-associated kindey injury(Day 0, Day 7 and On the day of discharge after improvement)
- Heat Stroke-associated liver injury(Day 0, Day 7 and On the day of discharge after improvement)