Technical Developments for High-field Brain Magnetic Resonance Spectroscopy
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Precision of quantification of brain metabolites concentrations
研究概览
简要总结
Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").
The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).
Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.
Aims
- To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).
- To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).
Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •over 18 years old
排除标准
- •no metallic implant or other MRI-incompatible device
结局指标
主要结局
Precision of quantification of brain metabolites concentrations
时间窗: One time only
This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques.
次要结局
未报告次要终点