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临床试验/NCT04064463
NCT04064463已完成不适用

Dual Reinforcement Contingency Management for Alcohol Use Disorders

UConn Health1 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2020年1月22日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
74
试验地点
1
主要终点
Alcohol abstinence

研究概览

简要总结

Phosphatidylethanol (PEth) is a direct biomarker of alcohol that can detect moderate to heavy drinking with high sensitivity and specificity over 3-week periods. Reinforcing negative PEth results alongside attendance may increase the proportion of participants who respond to CM during and post treatment. In the proposed study, the investigators will collect PEth samples every 3 weeks for 12 weeks in 150 participants initiating outpatient treatment for alcohol use disorders. Using a two-group randomized design, participants will be assigned to standard care with PEth monitoring alone or with CM for attending treatment and submitting PEth negative samples. Compared to standard care and monitoring, the investigators expect that the CM intervention will result in greater attendance, more PEth negative samples, and higher proportions of self-reported non-drinking days, along with lower proportions of heavy drinking days, over the short term and the long term, measured throughout a 12-month follow-up. The investigators anticipate that the reinforcement intervention may decrease other drug use and sexual risk behaviors that spread HIV, reduce psychiatric symptoms, and improve quality of life as well.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • in intensive outpatient treatment
  • DSM-5 diagnosis of an alcohol use disorder

排除标准

  • have a condition that may hinder study participation

研究组 & 干预措施

Control Group

Active Comparator

Standard care

干预措施: Standard care (Behavioral)

Experimental Group

Experimental

Standard care plus contingency management

干预措施: Standard care (Behavioral)

Experimental Group

Experimental

Standard care plus contingency management

干预措施: Contingency management (Behavioral)

结局指标

主要结局

Alcohol abstinence

时间窗: 12 weeks

number of negative PEth samples

Group attendance

时间窗: 12 weeks

longest consecutive days attended groups

次要结局

未报告次要终点

研究者

发起方
UConn Health
申办方类型
Other
责任方
Principal Investigator
主要研究者

Sheila Alessi

Associate Professor

UConn Health

研究点 (1)

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