Effect of vancomycin plus rifampicin in the treatment on methicillin-resistant Staphylococcus aureus pneumonia (Randomized prospective multicenter open-labelled study)

Asan Medical Center0 个研究点目标入组 266 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

暂无简介。

•Adult patients = 18 years of age will be screened daily for clinical signs and symptoms
•consistent with nosocomial pneumonia, i.e., one developed 48 h or later after admission.: had to meet two criteria (a,b)
•a. A patient had to have a chest radiograph consistent with the diagnosis of pneumonia (new or
•persistent radiographic infiltrates(new or progressive infiltrates, consolidation, with/without
•pleural effusion
•b. Modified CPIS (clinical pulmonary infection score) = 4

•a.presence ofmeningitis, endocarditis, or osteomyelitis
•b.bone marrow tranplantation or organ transplantation
•c.vancomycin treatment for = 48 h for any reason in the preceding week;
•d.elevated liver enzymes (= 3 times the upper limits of normal) or total bilirubin = 3.0 mg/dL
•e.severe neutropenia (< 1000 cells /mm3) or human immunodeficiency virus infection
•f.chemotherapy or persistent immunosuppression is needed
•g.a pathogen resistant to RFP or vancomycin

发起方