Investigating the effect of nano curcumin supplementation on drug craving, psychotic symptoms and serum levels A2A, TLR4 receptors and TNF-alpha, IL-6 factors in psychotic methamphetamine consuming patients.

Kashan University of Medical Sciences0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年3月6日

适应症

试验速览

暂无简介。

•Being at least 18 years old based on symptoms of methamphetamine psychosis to be admitted to the psychiatric ward.
•Use of methamphetamine more than two days a week for more than 1 year, as dependent on methamphetamine.
•Diagnosis of chronic methamphetamine use disorder based on the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition
•Based on the diagnosis of the senior research psychiatrist, having the symptoms of methamphetamine psychosis to be admitted to the psychiatric ward, one of the criteria of which is the positive and negative syndrome (PANSS), which was initially created for use in patients with schizophrenia, is one of the most reliable tools to assess the existence and the severity of psychotic symptoms.
•Having a minimum score of 10 and a maximum score of 70 for drug craving based on the questionnaire measuring the momentary drug craving (DDQ) to enter the intervention.
•People should not have a history of drug use (opium, opium juice, heroin, crack, and hashish).
•Completing the consent form.

•Unwillingness to cooperate at any stage of project implementation.
•Be dependent on drugs other than methamphetamine.
•People who are allergic to study and report side effects caused by taking medicine while studying.
•Taking curcumin and antioxidant and anti-inflammatory supplements in the last 3 months.
•The urine test for morphine, hashish and other drugs except methamphetamine will be checked three times for each person during the study, and if the test is positive, the patient will be excluded from the study.
•Pregnant women.
•Any past or current psychotic disorder, including manic episodes, schizophrenia, and schizoaffective disorder.

发起方