NL-OMON55167已完成不适用
Scope change in vasculitis: the role of monocytes and macrophages in ANCA-associated glomerulonephritis - MOMA study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 103
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet
- •following general and group-specific criteria:
- •1. Age: 18 years and older
- •Group-specific
- •Patients with ANCA-associated glomerulonephritis (AGN)
- •1. Diagnosed with granulomatosis with polyangiitis (GPA) or microscopic
- •polyangiitis (MPA)
- •2. Renal involvement attributable to vasculitis
- •3. History of PR3/MPO positivity as determined by ELISA in the context of
- •routine clinical care.
- •Hemodialysis controls
- •1. End stage kidney failure (ESRD) requiring hemodialysis
- •Active infection controls
- •1. Clinical diagnosis: pneumonia (CURB-65 score 2-5, imaging: X-thorax or
- •CT-thorax showing infiltrates) or complicated urine tract infection
- •2. Admitted to the hospital <48h
- •Nephrectomy controls
- •1. Patients who undergo a (partial) nephrectomy for treatment of a renal cell
- •carcinoma, who give consent for the use of surplus kidney tissue for research
- •Patients with (suspected) ANCA vasculitis with pulmonary involvement (API)
- •1. Suspected or diagnosed with ANCA-associated vasculitis
- •2. (Suspected) pulmonary involvement attributable to vasculitis
- •3. Patients who undergo a bronchoalveolar lavage (BAL) for diagnostic purposes
- •SLE patients with renal involvement
- •1. SLE diagnosis according to the 2019 EULAR/ACR Classification Criteria18
- •2. Renal involvement attributable to SLE
- •3. History of ANA positivity
排除标准
- •Patients with ANCA-associated glomerulonephritis (AGN) and Patients with
- •(suspected) ANCA vasculitis with pulmonary involvement
- •1. A history of drug-induced ANCA-associated vasculitis
- •2. Active infection as shown by microbiological analysis
- •Healthy controls and hemodialysis controls
- •1. Active infection as shown by microbiological analysis
- •2. A history of any auto-immune disease
- •3. Use of immunosuppressive medication
- •Infection controls
- •1. Other infection than pneumonia/urine tract infection
- •2. A history of any auto-immune disease
- •3. Use of immunosuppressive medication
- •SLE patients
- •1. A history of drug-induced SLE
- •2. Active infection as shown by microbiological analysis
研究者
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