Detection of Phosphorylated Alpha-synuclein Through Routine Colonoscopy to Diagnose Parkinson's Disease and Related Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Detection of phosphorylated alpha-synuclein in colon tissue samples
研究概览
简要总结
The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease. The main question it aims to answer is:
Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease?
Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.
详细描述
Brief Summary
What is this study about? This study is testing whether doctors can detect signs of Parkinson's disease by taking small tissue samples from the colon during a routine colonoscopy. Researchers want to see if they can find a specific protein called alpha-synuclein that builds up in people with Parkinson's disease.
Why is this study important? Currently, Parkinson's disease is diagnosed mainly by observing symptoms like tremors and movement problems. However, by the time these symptoms appear, the disease has already progressed significantly. Finding a way to detect the disease earlier could help doctors start treatment sooner and potentially slow down the disease.
Who can participate?
- Adults between 40-99 years old
- People who have already been diagnosed with Parkinson's disease
- People who are already scheduled to have a routine colonoscopy for colon cancer screening or other medical reasons
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults 40 to 99 years of age
- •Patients with a confirmed clinical diagnosis of Parkinson's disease by UKPDS Brain Bank Criteria
- •Patients who have agreed to undergo a routine colonoscopy as part of their surveillance for colon cancer or exclusion of other gastrointestinal diseases
排除标准
- •Use of anticoagulants (Plavix 75 mg or aspirin up to 325 mg alone is allowed)
- •History of colon cancer
- •Recent gastrointestinal illness or surgical procedures
- •Pregnant or planning to become pregnant before the scheduled colonoscopy
- •Significant cognitive impairment, as determined by study investigators
- •Decisionally impaired adults who cannot express understanding that this study is voluntary and for research purposes
结局指标
主要结局
Detection of phosphorylated alpha-synuclein in colon tissue samples
时间窗: At time of colonoscopy procedure
次要结局
未报告次要终点