Modulation of Visual-Spatial Learning in Healthy Older Adults by Transcranial Direct Current Stimulation - Proof of Principle and Mechanisms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Performance in LOCATO task (Visual-Spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
研究概览
简要总结
The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy older adults and to examine the underlying neuronal mechanism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(old healthy controls):
- •right handedness
- •unobtrusive neuropsychological screening
- •age: 50-90 years
排除标准
- •severe internal or psychiatric disease
- •other severe neurological diseases, e.g. previous major stroke or brain tumor
- •DMS-IV manifest dementia
- •contraindication for MRT (claustrophobia, metallic implants, tattoos)
研究组 & 干预措施
training + tDCS
Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS)
干预措施: tDCS (Device)
training + tDCS
Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS)
干预措施: training (Behavioral)
training + sham stimulation
Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation
干预措施: tDCS (Device)
training + sham stimulation
Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation
干预措施: training (Behavioral)
结局指标
主要结局
Performance in LOCATO task (Visual-Spatial learning and memory) after a combination of intensive visual-spatial training and tDCS
时间窗: immediately after the end of a 3 day training period in tDCS condition compared to sham condition
Investigation whether the combination of intensive visual-spatial training (LOCATO task) and tDCS leads to an improvement of visual-spatial learning and memory measured by performance in LOCATO task after end of a 3 day training period compared to sham stimulation.
次要结局
- functional changes: Connectivity(after end of 3-day period of training vs baseline)
- long term effects(after 1 month vs baseline)
- Quality of life(after 1 month vs baseline)
- affective state(immediately after the end of 3-day cognitive training, after 1 month vs. baseline)
- genotyping of learning related polymorphisms(once)
- cortical excitability(at baseline)
- memory(immediately after end of 3-day of cognitive training, after 1 month vs. baseline)
研究者
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany