NCT05521295招募中不适用
Microbiome Predicts Pregnancy Outcomes Undergoing Frozen Embryo Transfer: A Multicenter Prospective Observational Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,600
- 试验地点
- 1
- 主要终点
- Conception
研究概览
简要总结
This study intends to explore the correlation between cervical microbiome, gut microbiome and pregnancy outcomes of frozen embryo transfer patients through a multicenter prospective observational study, and to explore the predictive value of microbiome on pregnancy outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Infertile women receiving assisted reproductive technology treatment, preparing for frozen embryo transfer cycle;
- •Female age: 20-45 years old;
- •Single frozen-thawed blastocyst Transferred
- •Endometrial thickness ≥7mm on the day of luteal transformation
- •Written informed consent.
排除标准
- •Women who have pathologies or malformations that affect the pregnancy outcome:genital malformations, intrauterine adhesions, uterine fibroids (>4 cm in diameter or compressing endometrial line), adenomyosis, endometrial polyps; untreated tubal pleura Presence of autoimmune disease;
- •Untreated hyperprolactinemia, thyroid disease, adrenal disease
- •Antibiotic use within the past 7 days;
- •Current or recent (within 3 months) drug abuse, including alcohol and tobacco;
- •Refused or unable to comply with protocol requirements;
- •Participation in any experimental drug study within 60 days prior to screening.
结局指标
主要结局
Conception
时间窗: 09.01.2022 to 09.01.2024
Concentration of serum human chorionic gonadotropin ≥10 mIU/mL
次要结局
- Clinical pregnancy(09.01.2022 to 09.01.2024)
研究者
Xiuxia Wang
Principal Investigator
Shengjing Hospital
研究点 (1)
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