跳至主要内容
临床试验/NCT07510854
NCT07510854招募中不适用

Sentence Prediction in Developmental Language Disorder

Father Flanagan's Boys' Home1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2026年2月16日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
80
试验地点
1
主要终点
Behavioral response data

研究概览

简要总结

Millions of children - 7-12% of the school-age population - have developmental language disorder (DLD), a disorder that affects language learning, comprehension, and use. These children have difficulty with sentence production and comprehension at every stage of their development. These difficulties have major implications for the educational attainment of children with DLD compared to children with typical development (TD). Children with TD and adults make rapid predictions of upcoming words following verbs (e.g., predicting the patient in The dog eats the bone or the agent in The bone is eaten by the dog). Extensive work in children and adults indicates that prediction facilitates sentence comprehension by inducing a state of preparedness and contributes to language development by tuning the language system to the input. Children with DLD have a poorer ability to make sentence predictions, which may compound and result in sentence-comprehension deficits. Prior work on prediction deficits in DLD has focused on broad sentence characteristics like typicality or broad participant characteristics like vocabulary test scores. However, studies with typical individuals have identified more specific sentence- and participant-level contributors to sentence prediction. These factors have not been systematically explored in children with DLD. The investigators explore three separate hypotheses concerning factors that affect prediction in DLD. First, sentence- and participant-level properties affect prediction in children with DLD. Second, children with DLD lack robust representations of the underlying linguistic knowledge needed to predict, particularly abstract semantic features. Third, children with DLD have differences in event processing that relate to sentence prediction skill. The investigators investigate these hypotheses in 5-7-year-old school-age children with DLD across three Aims. Aim 1: Measure the effect of sentence- and participant-level properties on sentence prediction. The investigators will measure two participant-level cognitive factors (processing speed, verbal working memory) and their effect on prediction of agents and patients in sentences varying across two properties (syntactic complexity, semantic competition). Aim 2: Measure linguistic knowledge that underlies sentence prediction. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-<round object>). Aim 3: Measure event-processing skills that underlie sentence prediction. The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes. Impact: This project has the promise to be highly impactful. First, it bridges disparate literatures on language processing in adults, children with TD, and children with DLD, providing clarity about predictive processing in DLD. Second, it may influence intervention approaches by identifying areas of strength and need in children with DLD. Third, it sets the stage for larger-scale longitudinal work examining effects of early prediction ability, language knowledge, and event processing on later sentence comprehension.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
5 Years 至 7 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Pass a hearing screening at 25dB at 0.5, 1, 2, and 4 kHz
  • Have normal or corrected-to-normal vision
  • Have no history of neurological disorders
  • For DLD group, Test of Narrative Language 2 (TNL-2) score less than 92
  • For TD group, TNL-2 score greater than 92, a cut-off that provides excellent sensitivity/specificity (.92/.92).

排除标准

  • Scores in the Autism range on the Childhood Autism Rating Scale 2 (CARS-2)
  • Scores below 75 on the Visual Spatial Index of the Wechsler Preschool and Primary Scale of Intelligence 4 (WPPSI-IV)

研究组 & 干预措施

Measure verb knowledge, sentence processing, and event processing

Experimental

The investigators will measure participant-level cognitive factors and their effect on prediction of agents and patients in sentences varying across syntactic complexity and semantic competition. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-<round object>). The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes.

干预措施: Thematic role (Behavioral)

Measure verb knowledge, sentence processing, and event processing

Experimental

The investigators will measure participant-level cognitive factors and their effect on prediction of agents and patients in sentences varying across syntactic complexity and semantic competition. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-<round object>). The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes.

干预措施: Sentence complexity (Behavioral)

结局指标

主要结局

Behavioral response data

时间窗: During sessions for verb knowledge tasks

For verb knowledge tasks, the investigators will measure children's button presses for accuracy.

Eye tracking gaze data

时间窗: During sessions for sentence processing and event processing tasks

During sentence processing and event processing, the investigators will measure children's looking to one or more images presented on-screen as a sentence is played (Aim 1) or as they point to images (Aim 3). The investigators will analyze how intervention conditions (thematic role and sentence complexity) influences children's looking patterns.

次要结局

  • Behavioral response data(During sessions for verb knowledge tasks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Justin Kueser

Research Scientist

Father Flanagan's Boys' Home

研究点 (1)

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