跳至主要内容
临床试验/CTRI/2018/05/013866
CTRI/2018/05/013866已完成Unknown

Comparison of the Post- Operative Analgesia in Haemorrhoidectomy patients after Peripheral Block using DEXMEDETOMIDINE VS CLONIDINE

Sree Gokulam Medical College And Research Foundation1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2014年10月24日最近更新:

试验速览

阶段
Unknown
状态
已完成
发起方
入组人数
60
试验地点
1
主要终点
Duration of post-operative analgesia

研究概览

简要总结

A study was conducted to compare the duration of post-operative analgesia in patients undergoing haemorrhoidectomy who are given pudendal nerve block with either Clonidine or Dexmedetomidine alongwith local anaesthetic Bupivacaine in the operation theatre of Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Trivandrum, Kerala. 60 patients were randomly divided into two groups of 30 each -- group C underwent pudendal block with 20ml of 0.25% Bupivacaine with Clonidine 1mcg / kg as additive  and group D underwent pudendal block with 20ml of 0.25% Bupivacaine with Dexmedetomidine 1mcg/kg as additive . Complications like sedation, bradycardia and hypotension were also studied.  The data was entered in excel and analysed using SPSS 20.0 and compared using t test and chi square test. There was significant difference in the duration of post-operative analgesia between the two groups. The duration of analgesia in group C was 761 +/_ 19.1 minutes while in group D it was  1184.57 +/_ 151.374 minutes. In pudendal nerve block, addition of Dexmeditomidine as an adjuvant to 0.25% Bupivacaine prolongs the duration of post-operative analgesia and is not associated with any major side effects. Both drugs have an added advantage of conscious sedation and haemodynamic stability, making them potential adjuvants for nerve blocks.

研究设计

研究类型
Interventional
分配方式
Computer generated randomization
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • BMI<30 Normal coagulation parameters and platelet count(>100000) No systemic infection.

排除标准

  • BMI>30 Severe liver renal or cardiac disease Allergy or contraindications to any of the study drugs Previous surgery in the anal canal Pain or chronic analgesic administration in the preoperative period Abnormal coagulation parameters and platelet count(<100000) Systemic infection Patient requesting general anaesthesia.

结局指标

主要结局

Duration of post-operative analgesia

时间窗: Post operative monitoring for 24 hours

次要结局

  • Post operative haemodynamic stability(1,5,10,30,60,120,180,240,360,480,600,720 min after completion of injection)
  • Sedation(Every 30 minutes for 24 hours during the postoperative period)

研究者

发起方
Sree Gokulam Medical College And Research Foundation
申办方类型
Private medical college

研究点 (1)

Loading locations...

相似试验