A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Electromyography (EMG) response following Transcranial Magnetic Stimulation (TMS)
研究概览
简要总结
The objective of the study is to use neurological techniques to obtain quantitative measurements of nervous system control of skeletal muscle activity in adults aged 60-85 who are either long-term resistance exercisers or who are untrained.
详细描述
We propose to perform a cross-sectional study in 20-40 highly resistance-trained people and compare with 20-40 untrained people matched for age, sex, and BMI. in adults.
Participant will complete 5 study visits. In the first visit, participants will complete a screening visit in which blood will be taken to rule out inclusion and exclusion criteria. Participants will also have their body composition measured by DEXA, Meal tolerance testing, a VO2max test on a cycle ergometer, and a muscle strength test using a knee extension machine, handgrip dynamometer and muscle motion testing.
A second and third visit will be needed for meal tolerance testing will be completed and MRI of the brain.
In the fourth and fifth visits, we will use transcranial magnetic stimulation (TMS) with electromyography (EMG) to track changes in in skeletal muscle excitability following cortical stimulation.
In the third visit, TMS-EMG measurements will be repeated to access measurement reproducibility.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant must have a BMI between 18.5 and 38
- •Participant be aged between 60 and 85
- •Regularly exercises at least 5 days a week a minimum of 30 minutes per day.
- •Engages in less than 2 days of exercise less than 30 minutes each day.
- •Participant must use the Mayo Clinic patient online portal.
- •Participant must be able to understand English without the need of an interpreter.
- •Must be willing to be contacted for research
- •Participant must be willing and capable to provide consent.
- •Participants shall be generally healthy as deemed acceptable by the principal investigator
- •Men and women will be participant in this study. Women cannot be pregnant during this study.
排除标准
- •Surgical History - Gastric surgery, pacemaker placement, weight loss surgery, metabolic and obstetric surgery.
- •Smokers will be excluded from the study.
- •Medications: Insulins, common diabetic drugs, anti-hyperglycemic drugs, beta blockers cardiac selective, beta-blockers noncardiac selective, oral steroids, opioids anti-depressants, and hormones
- •Conidiations and Diagnosis: Disorder of coronary artery, hepatic failure, gastroparesis, disorder of the adrenal gland, drug related disorders, substance abuse, malignant neoplastic disease, psychotic disorders, disorder of skeletal muscle, finding of brain, chronic kidney disease, renal failure syndrome, disorder of pulmonary circulation, cerebrovascular disease, neuro developmental disorder, disorder of immune function, disorder of central nervous system.
- •Participants are not to have an abnormal value as part of a lipid panel within the past 6 months.
- •Participant will be excluded if they have recreational drug use or a history of alcohol abuse
- •Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
- •Current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention.
- •Participant will be excluded if they have epilepsy.
- •Participant will be excluded if they have cranial metal/device implants
- •Participant will be excluded if they are pregnant
研究组 & 干预措施
Highly resistance-trained
干预措施: Mixed Meal Tolerance Test (Diagnostic Test)
Untrained
干预措施: Neuromuscular Test (Diagnostic Test)
Untrained
干预措施: DEXA (Diagnostic Test)
Untrained
干预措施: Mixed Meal Tolerance Test (Diagnostic Test)
Untrained
干预措施: Strength Test (Diagnostic Test)
Highly resistance-trained
干预措施: Neuromuscular Test (Diagnostic Test)
Highly resistance-trained
干预措施: Strength Test (Diagnostic Test)
Highly resistance-trained
干预措施: DEXA (Diagnostic Test)
结局指标
主要结局
Electromyography (EMG) response following Transcranial Magnetic Stimulation (TMS)
时间窗: 21 days
To assess connectivity between the nervous system and skeletal muscle, we will use transcranial magnetic stimulation (TMS) coupled with electromyography (EMG). TMS uses a magnetic field to carry a short-lasting electrical current pulse into the brain where it stimulates neurons, particularly in superficial regions of cerebral cortex, and neural activities can be measured at different levels along the motor pathways (predominantly the CST). When combined with EMG, this approach will allow us to quantify changes in muscular activity after stimulating the CST and other descending tracts and to assess the neuromuscular connectivity. EMG assess the health of muscles and the nerve cells that control them (motor neurons). EMG results can reveal nerve dysfunction, muscle dysfunction or problems with nerve-to-muscle signal transmission. Motor neurons transmit electrical signals that cause muscles to contract. Electrodes will then translate signals into graphs, sounds or numerical values.
次要结局
未报告次要终点
研究者
K. Sreekumaran Nair
Principal Investigator
Mayo Clinic