Quality of Life in Patient With Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Gastric Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- Quality of life index
研究概览
简要总结
The purpose of this study is to explore the influence of neoadjuvant chemotherapy in the long term quality of life with advanced gastric cancer patients.
详细描述
Preoperative adjuvant chemotherapy combined with postoperative adjuvant therapy mode was included in the 2018 version of the National Comprehensive Cancer Network (NCCN) guideline as an optional treatment (category 2B) for prospective resectable advanced gastric cancer cases (≥cT2, any N).At home and abroad, the research on neoadjuvant chemotherapy for advanced gastric cancer mainly focuses on the safety and long-term survival, and there are few studies on the quality of life. This study, according to EORTC QLQ-C30 and QLQ-STO22 assessment scale, explores the long term effect of neoadjuvant chemotherapy on the quality of life in patients with advanced gastric cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients age older than 18 years (including 18 years old);
- •Diagnosis of adenocarcinoma of the stomach
- •The clinic stage is ≥T2 and any N stage
- •Patient had curative surgical resection, including proximal, distal, or total gastrectomy
排除标准
- •Psychiatric or psychological abnormality precluding informed consent or ability to complete questionnaires
- •Non-psychiatric disorder causing a lack of capacity to give consent or an inability to complete questionnaires (ie dementia, stroke)
- •Early gastric cancer.
研究组 & 干预措施
NACS
The patients with advanced gastric cancer who received neoadjuvant chemotherapy followed by surgery（NACS）.
干预措施: Neoadjuvant Chemotherapy (Drug)
结局指标
主要结局
Quality of life index
时间窗: 2 years
The change of quality of life index during the 2 years after surgery.
次要结局
未报告次要终点
研究者
Xiangqian Su
Chief of GI surgery IV
Peking University Cancer Hospital & Institute