NCT07662382尚未招募不适用
Comparison of Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation From Cousin Donors Versus Sibling Donors in Patients With Hematological Malignancies: A Target Trial Emulation Study
The First Affiliated Hospital of Soochow University1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2026年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
研究概览
简要总结
This observational study aims to emulate a hypothetical pragmatic, multicenter, non-blinded clinical trial enrolling adult patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with grafts derived from either cousin or sibiling donors.
The main research question is whether cousin donor-derived haplo-HSCT is associated with inferior clinical outcomes relative to sibling donor-derived haplo-HSCT.
Study participants consist of adult patients diagnosed with hematological malignancies who underwent cousin or sibiling haplo-HSCT between 2017 and 2024, and all eligible recipients will receive regular follow-up assessments.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients diagnosed with hematological malignancies, including acute leukemia (AL), chronic myeloid leukemia (CML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and non-Hodgkin lymphoma (NHL)
- •Receipt of first haploidentical hematopoietic stem cell transplantation between 2017 and 2024
- •Documented exact date of transplantation available in medical charts
- •Verifiable donor kinship classified as either cousin or sibiling
- •Complete longitudinal follow-up data accessible for outcome assessment
排除标准
- •Prior receipt of any form of hematopoietic stem cell transplantation
- •An age difference of more than 18 years between the donor and recipient
- •Failure of successful infusion of donor-derived hematopoietic stem cells following conditioning regimen
研究者
研究点 (1)
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