Thyroid Dysfunction and Its Association With Metabolic Dysfunction-Associated Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Level of free triiodothyronine (FT3)
研究概览
简要总结
This study aims to evaluate the prevalence of thyroid dysfunction and its association with metabolic dysfunction-associated fatty liver disease.
详细描述
One of the most common causes of chronic liver diseases worldwide is metabolic dysfunction-associated fatty liver disease (MAFLD), which affects about 30% of adults. Thyroid hormones are critical in maintaining metabolic homeostasis throughout life and are intimately linked to the liver.
Dysfunctions of the thyroid gland have been implicated as one of the most important risk factors of MAFLD due to its important role in the hepatic synthesis of fatty acid and cholesterol. Maintaining liver metabolism requires thyroid function to be normal, while thyroid disorders may lead to liver disease progression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years.
- •Both sexes.
- •Patients with metabolic dysfunction-associated fatty liver disease (MAFLD).
排除标准
- •History of thyroid disease or treatment (e.g., thyroid nodules, thyroid cancer, hypothyroidism, and hyperthyroidism).
- •Patients with alcoholic liver disease take more than 40g of alcohol (or four units) per day.
- •Viral hepatitis.
- •Pregnant women.
结局指标
主要结局
Level of free triiodothyronine (FT3)
时间窗: After the sample is taken (up to 5 minutes)
Free triiodothyronine (FT3) will be measured using chemiluminescent immunoassay analysis.
次要结局
- Level of free thyroxine (FT4)(After the sample is taken (up to 5 minutes))
- Level of thyroid stimulating hormone(After the sample is taken (up to 5 minutes))
- Relation between gender and thyroid function(After the sample is taken (up to 5 minutes))
- Correlation between metabolic data and thyroid function tests(After the sample is taken (up to 5 minutes))
研究者
Shimaa Abdelmounem Meshaal
Lecturer of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University