Study of the therapeutic effect of nanoestrutured pharmaceutical preparation incorporated with Pequi Oil (Caryocar Coriaceum) in the functionality of patients with Gonartrosis.

Fundação Universidade Federal do Sergipe0 个研究点开始时间: 2018年4月29日最近更新: 2023年5月29日

试验速览

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•Be over 50 years old; Radiography showing grade 2 to 4 gonarthrosis according to the Kellgren-Lawrence scale (KELLGREN, et al., 1957); Pain in the knee; Complete at least one of the American College of Rheumatology (ALTMAN, et al., 1986) classification criteria.
•According to Kellgren-Lawrence (1957), changes in X-rays caused by osteoarthrosis are classified as: normal (grade 0); possible narrowing of joint space and defined osteophyte (Grade II); defined narrowing of the joint space, multiple moderate osteophytes, some subchondral sclerosis and possible deformity of the bone contour (Grade III); articular space narrowing, severe subchondral sclerosis, defined deformity of the bone contour and presence of large osteophytes (Grade IV).
•The classification criteria of the American College of Rheumatology are (ALTMAN, et al., 1986): Clinical and physical evaluation (knee pain and three of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, bone fragility, joint heat). Clinical, physical and radiographic evaluation (knee pain and one of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, crackling of the active movement and presence of osteophytes).
•Clinical, physical, and laboratory evaluation (knee pain and five of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, bone fragility, bone enlargement, joint heat, crackling to active movement.

•Presence of autoimmune diseases; Open wounds or skin lesions in the knee region; Chronic diffuse pain (fibromyalgia); Cancer.

发起方

Fundação Universidade Federal do Sergipe