Study of Reality-monitoring Process and Influence of Stress Using an Electrophysiological Approach
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Reality-monitoring performances
研究概览
简要总结
Reality-monitoring is a crucial cognitive process in daily life to remember the source of an information. Deficits of reality-monitoring have been shown into the continuum of schizophrenia, suggesting a preexisting alteration in population at-risk for psychosis that will be exacerbated during psychotic transition. It is admitted that stress plays a crucial role in the psychotic transition and can alter cognitive performances. However, less is known about the effects of stress on reality-monitoring, even though this process appears to be central in psychotic disorders.
The aim of this project is to investigate the effect of stress on reality-monitoring, both on behavioral and neurophysiological aspects
详细描述
Forty healthy subjects will be included in the study. Participants will be subject to a standardized stress protocol, half of them receiving an active stress and the other half receiving a placebo. All participants will also complete a reality-monitoring task, electrophysiological (EEG) recordings as well as socio-demographic and psychometric evaluations
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants will not be informed about the nature (active or placebo) of the stress test they will perform.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right-handed Men and Women aged between 18 and 30
- •Having given their written informed consent
- •For women: oral contraceptive use
- •French speakers and readers
排除标准
- •Do not consent to be included in the study
- •Night workers
- •Having visual or hearing impairments that could prevent the successful completion of tasks involving reading or listening to sounds
- •Taking drug treatment (except oral contraceptive)
- •Having a somatic pathology in particular neurological, endocrinal or blood circulation diseases (e.g., Raynaud's disease)
- •Having personal or first-degree relatives' history of diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5)
- •Having psychotic prodomes measured by a score above 6 in the "prodomal questionnaire' - PQ-16 (Ising et al., 2012)
- •Having developed musical abilities (that is, regularly practicing a musical instrument)
- •Being pregnant or nursing
结局指标
主要结局
Reality-monitoring performances
时间窗: within 1 hour after the stress procedure
scores obtained at the reality-monitoring task (accuracy, range 0-100%)
次要结局
- Subjective stress(1 time before and 1 time 1 hour after the stress procedure)
- electroencephalogram (EEG) activity(1time within 1 hour after the stress procedure)
- Working memory(1 time within 1 hour after the stress procedure)
- Heart rate(throughout and within 1 hour after the stress procedure)
- Blood pressure(throughout and within 1 hour after the stress procedure)
- Salivary cortisol(throughout and within 1 hour after the stress procedure)
- Psychometric characteristics that may influence stress response (1)(Basline, before the stress procedure)
- expression rate of genes involved in the regulation of the glucocorticoid receptor signaling pathway(1 time before and 1 time 1 hour after the stress procedure)
- Basic auditory performances(1 time within 1 hour after the stress procedure)
- Psychometric characteristics that may influence stress response (3)(Basline, before the stress procedure)
- Psychometric characteristics that may influence stress response (2)(Basline, before the stress procedure)
- Psychometric characteristics that may influence stress response (4)(Basline, before the stress procedure)
- Psychometric characteristics that may influence stress response (5)(Basline, before the stress procedure)