NCT05219994已完成不适用
Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Insulin change in response to OGTT
研究概览
简要总结
Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •type 2 diabetes
- •BMI 18-40 kg/m2,
- •non-pregnant,
- •non-breastfeeding,
- •non-nicotine users.
排除标准
- •cardiovascular disease including myocardial infarction, heart failure, coronary artery disease, stroke;
- •renal or hepatic diseases;
- •active cancer;
- •autoimmune diseases;
- •immunosuppressant therapy;
- •excessive alcohol consumption (>14 drinks/week);
- •current nicotine use;
- •foot ulcers;
- •diabetic neuropathy;
- •medication directly influencing sympathetic nervous system activity
结局指标
主要结局
Insulin change in response to OGTT
时间窗: 2 hours post glucose ingestion
Glucose change in response to OGTT
时间窗: 2 hours post glucose ingestion
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Assistant Professor
University of Missouri-Columbia
研究点 (2)
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