Transcranial Direct Current Stimulation (tDCS) to Improve Maximal Aerobic Performance in Recreational and Trained Runners
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 2
- 主要终点
- Time to exertion (active vs. sham)
研究概览
简要总结
Many different factors affect running performance, transcranial direct current stimulation (tDCS) is a widely used and available neuromodulation tool and could hypothetically facilitate the supraspinal drive and thereby act upstream of the motor cortex to prolong the muscles work in time to exhaustion trials. While it appears to decrease the rating of perceived exertion (RPE) during cycling, little is known about the effects of tDCS on physiological performance parameters such as maximal oxygen consumption (VO2max), maximal aerobic speed (MAS) and lactate thresholds in runners.
The aim of this prospective randomized sham-controlled clinical trial is to investigate the physiological effects of tDCS applied over the motor cortex on perceived exertion and performance-related parameters measured by an incremental treadmill test to exhaustion.
This research thus aims at answering the following questions:
- Is active tDCS applied bilaterally over the motor cortex significantly more efficient than sham tDCS to improve the TTE?
- Does active tDCS decreases the RPE, as compared to sham?
- Is there any significant difference between active and sham tDCS on the physiological parameters measured during an incremental test to exhaustion, namely: VO2max, MAS, respiratory exchange ratio, blood lactate levels, maximal heart rate?
- Does the baseline level of physical fitness influences response to tDCS?
The investigators hypothesize that 1) performance as measured by time to exertion will be increased following active and not sham tDCS due to a decreased perceived rate of exertion without significantly altering the other physiological parameters; and 2) performance as measured by incremental treadmill test to exhaustion will be more improved in recreational as compared to trained runners.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subject
- •Regular running activity above 2 hours/week
- •VO2max above 30 mL/min/kg
排除标准
- •Pacemaker
- •Intracerebral metallic implant
- •Using dietary supplementation or medication potentially affecting the CNS
- •Musculoskeletal injury within the past 6 weeks
结局指标
主要结局
Time to exertion (active vs. sham)
时间窗: Immediate
Time to achieve exhaustion during a treadmill test where the speed is set at a constant 90% of the individual maximal aerobic speed (determined during the screening visit)
次要结局
- Maximal Oxygen Consumption (VO2max) evolution (active vs. sham)(Immediate)
- Lactate thresholds (active vs. sham)(Every 3 minutes during the test to exhaustion until the end of the test (up to 1 hour after the stimulation))
- Ratings of perceived exertion (RPE) evolution (active vs. sham)(Every 3 minutes during the test to exhaustion until the end of the test (up to 1 hour after the stimulation))
研究者
Géraldine Martens
Principal Investigator
University of Liege