A Placebo-Controlled Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS-Associated Kaposi's Sarcoma
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 22
研究概览
简要总结
To determine whether taking zidovudine (AZT) will change the natural course of HIV infection in patients with AIDS-associated Kaposi's sarcoma (KS) and whether administering AZT at a similar dose but at different intervals will reduce toxicity in a more manageable treatment plan.
Patients infected with AIDS can benefit from therapy with an effective anti-AIDS virus agent. AZT is a drug that is effective in inhibiting the effects of HIV infection. The study will show whether toxicity of AZT can be reduced in a more manageable treatment plan, and whether AZT therapy will delay the development of opportunistic infections and/or KS lesions.
详细描述
Patients infected with AIDS can benefit from therapy with an effective anti-AIDS virus agent. AZT is a drug that is effective in inhibiting the effects of HIV infection. The study will show whether toxicity of AZT can be reduced in a more manageable treatment plan, and whether AZT therapy will delay the development of opportunistic infections and/or KS lesions.
Patients are divided into two treatment groups, the first receiving AZT for 5 doses a day, and the second receiving AZT for 3 doses per day. A placebo group is divided into two to match the two treatment groups. Study patients are stratified according to whether they have (a) 10 or fewer cutaneous lesions without oral lesions or (b) more extensive cutaneous lesions or oral lesions. Patients are seen on an outpatient basis weekly for the first 2 months, every other week for the next 2 months, and monthly thereafter.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Concurrent Medication:
- •Acute treatment for mucocutaneous candidiasis, localized cutaneous herpes simplex, or localized or disseminated zoster infections.
- •Concurrent Treatment:
- •Blood transfusion for treatment of Grade 3 hemoglobin toxicity if the patient's cardiovascular status is compromised or if the hemoglobin fails to show signs of recovery following withdrawal from the study drug. Toxicity grades according to NIAID Recommendations for Grading Acute and Subacute Toxic Effects (Adults).
- •Patients must have:
- •HIV-related, biopsy-proven Kaposi's sarcoma mucocutaneous lesions without constitutional symptoms.
排除标准
- •Co-existing Condition:
- •Patients with the following conditions will be excluded:
- •Symptomatic, visceral Kaposi's sarcoma.
- •Lymphedema.
- •HIV neurologic disease as determined by a standard neurologic examination and neuropsychological questionnaire.
- •Concurrent Medication:
- •Aspirin or acetaminophen on a regular basis or for longer than 72 hours without approval of investigator.
- •Cimetidine.
- •Flurazepam.
- •Indomethacin.
- •Ranitidine.
- •Probenecid.
- •Drugs causing anemia, neutropenia, or significant risk of nephrotoxicity.
- •Prophylaxis or chronic suppression of herpes simplex.
- •Treatment of herpes simplex virus cutaneous disease more often than once a month for 5 - 7 days.
- •Concurrent Treatment:
- •Radiation therapy for treatment of Kaposi's sarcoma lesions.
- •The following patients will be excluded from the study:
- •Patients with a history of any AIDS-defining opportunistic infection.
- •Patients with any of the following constitutional symptoms with no etiology established:
- •Temperature more than 38 degrees and/or drenching night sweats for more than 1 month; watery diarrhea for 2 or more weeks; weight loss of more than 10 percent.
- •Patients with a history of other systemic malignancies or lymphomas.
- •Prior Medication:
- •Systemic antineoplastic chemotherapy.
- •Zidovudine (AZT).
- •Excluded within 30 days of study entry:
- •Antiretroviral agents.
- •Immunomodulating agents.
- •Prophylaxis for Pneumocystis carinii pneumonia.
- •Prophylaxis for herpes simplex virus infections.
- •Any other experimental therapy.
- •Prior Treatment:
- •Excluded within 30 days of study entry:
- •Any experimental therapy.
- •Active substance abuse.