Hemodynamic Response of Rifaximin plus Non-selective ß-blocker versus non-selective ß-blocker monotherapy in Cirrhotic Patients with esophageal varices.

Yonsei University, Wonju Severance Christian Hospital0 个研究点目标入组 140 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

暂无简介。

•1.Liver cirrhosis:diagnosed based on histology or unequivocal clinical, sonographic, and laboratory findings
•2.Esophageal varices, F2 or F3
•3.Hepatic venous pressure gradient > 12mmHg
•4.Informed consent

•1.Shock status requiring vasopressor
•2.Active infection, for example Spontaneous bacterial peritonitis
•3.Acute renal failure patients of any cause
•4.Clinically relevant coronary artery disease(NYHA functional angina classification III/IV),congestive heart failure NYHA III/IV), clinically relevant cardiomyopathy, history of myocardial infarction in the past 12 months
•5.Poorly controlled hypertension (BP 150/100mmHg)
•6.Hepatocellular carcinoma
•7.History of another primary malignancy = 3years
•8.Medical or psychological conditions that would not permit the subject to complete thte study or sign informed consent
•9.Pregnancy or lactation period
•10.Serum creatinine ? 6mg/dL
•11.Involvement in the conduct of other study within 30 days
•12.Known hypersensitivity to Rifaximin or propranolol
•13.Dysarrhythmia, inappropriate for study on investigator's judgment

发起方

Yonsei University, Wonju Severance Christian Hospital