Interpersonal Brain Function in Opioid Use
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Neurophysiological synchrony
研究概览
简要总结
The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with opioid-related outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Persons, aged 18 or older
- •Current near daily use of prescribed or illicit opioid agonists or mixed opioid agonist-antagonists for ≥90 days
- •Must be able to speak and understand English
排除标准
- •Cognitive Impairment that would preclude participation in the research protocol
- •Active suicidal intent or psychosis
研究组 & 干预措施
Meditation
20 minutes of guided meditation during the laboratory session involving mindfulness of breathing and lovingkindness practice.
干预措施: Meditation (Behavioral)
Psychoeducation
Psychoeducation about opioid neuropharmacology.
干预措施: Psychoeducation (Behavioral)
结局指标
主要结局
Neurophysiological synchrony
时间窗: During the intervention and for 5 minutes afterwards
Dyadic Neural Synchrony (DNS) across electrodes and dyads will be computed from EEG oscillations using established inter-brain connectivity metrics. DNS will be quantified as a dyadic coupling parameter computed from time-series features extracted from each participant's EEG activity. Higher DNS values indicate greater therapist-patient neural attunement.
次要结局
- Interpersonal Attunement(During Intervention)
- Opioid Craving(Pre-Intervention, during Intervention, immediately post-Intervention, and at 1 month follow-up)
- Opioid Use(Pre-Intervention, and 1 month Follow-Up)
- Severity of Pain(Pre-Intervention, during Intervention, immediately post-Intervention, and at 1 month follow-up)
- Affect(Pre-Intervention, during Intervention, and immediately post-Intervention.)
- State Self-Transcendence(Pre-Intervention, during Intervention, immediately post-Intervention.)
- Metacognitive processes(Pre-Intervention, during Intervention, and immediately post-Intervention.)
- Cardiac-autonomic synchrony(During the intervention and for 5 minutes afterwards)
- Facial expression synchrony(During the intervention and for 5 minutes afterwards)
研究者
Eric Garland
Professor of Psychiatry
University of California, San Diego