NCT05858814招募中1 期
A Phase I/II Clinical Trial of RC1012 Injection for the Prevention of Relapse in AML Patients After Allogeneic Hematopoietic Stem Cell Transplantation
Guangdong Ruishun Biotech Co., Ltd1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2023年5月4日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Maximum Tolerated Dose (MTD)
研究概览
简要总结
To evaluate the safety and tolerability of RC1012 injection infusion in AML Patients after Allo-HSCT
详细描述
This study aims to evaluate the safety and tolerability of RC1012 injection infusion in AML Patients after Allo-HSCT.
DNT cells are mature T lymphocytes that comprise 3-10% of T cells in human peripheral blood mononuclear cells (PBMC). Allo-DNT cells from healthy donors have been proved to be safe and demonstrated potent cytotoxicity against AML blasts from AML patients in preclinical and preliminary clinical studies. Allo-DNT cells will be collected from healthy donors (NO MHC match needed) and infused into patients. The drug for this study is an off-the-shelf product. Patients DO NOT need to wait for the cell manufacturing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Voluntarily sign an ICF and expect to complete the study procedures for follow-up examinations and treatment.
- •Aged 18 to 70 years (including cut-offs), regardless of gender.
- •Subject must be diagnosed with AML according to World Health Organization (WHO) criteria (2016).
- •The subject has received an allogeneic HSCT within 60-100 days, the percentage of malignant primitive cells in the bone marrow is < 5% after HSCT and STR-PCR shows complete donor chimerism.
- •The subject has one of the following high-risk factors for relapse after allo-HSCT: (1) Failure to achieve remission after two courses of induction chemotherapy. (2) Prior history of Myelodysplastic Syndromes (MDS) or Myeloproliferative Neoplasm (MPN). (3) High leukocytes (≥100×10^9/L) combined with Central Nervous System Leukemia (CNSL); (4) Positive Minimal Residual Disease (MRD) before HSCT; (5) Non-remission or disease progression prior to HSCT; (6) Subject with cytogenetic high-risk factors (except that who can be treated with targeted drugs).
- •The subject has recovered from the toxicity of the prior treatment, i.e., CTCAE toxicity grade <2 (unless the abnormality is tumor-related).
- •ECOG score 0 to
- •With appropriate organ function:
- •Glutathione aminotransferase (AST) ≤ 3 times the upper limit of normal (ULN);
- •Glutamic aminotransferase (ALT) ≤ 3 times ULN;
- •Total bilirubin ≤ 1.5 times ULN, unless the patient has documented Gilbert syndrome. Patients with Gilbert-Meulengracht syndrome with total bilirubin ≤ 3.0 times ULN and direct bilirubin ≤ 1.5 times ULN may be included;
- •Serum creatinine ≤ 1.5 times ULN or a creatinine clearance ≥ 60 ml/min;
- •Hemoglobin ≥ 80 g/L or hemoglobin maintained at that level following transfusion;
- •International Normalized Ratio (INR) ≤ 1.5 times ULN and Activated Partial Thromboplastin Time (APTT) ≤ 1.5 times ULN;
- •Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L.
- •A platelet count ≥ 50 x 10^9/L or a platelet count maintained at that level following a platelet transfusion;
- •Left ventricular ejection fraction (LVEF) ≥ 45%.
- •Female patients with childbearing potential should have a negative pregnancy test during the screening period. Any male and female patients of childbearing potential must agree to use an effective contraception method for at least six months from the time that they sign the informed consent form until the end of the cell infusion. Female patients without childbearing potential (meeting at least 1 of the following criteria) is described below.
- •Have undergone a hysterectomy or bilateral oophorectomy;
- •Medically recognized as ovarian failure;
- •Medically recognized as post-menopausal (at least 12 consecutive months of menopause without pathological or physiological cause).
排除标准
- •Subject is confirmed to have morphological relapse of leukemia or positive MRD after allo-HSCT.
- •Subject with extramedullary infiltration of leukemia.
- •Suffer from other malignancies within 5 years prior to screening, except adequately treated carcinoma in situ of the cervix, basal cell or squamous epithelial cell skin cancer, post-radical thyroid cancer, and post-radical ductal carcinoma in situ.
- •Has severe respiratory disease (previous or combined history of severe interstitial lung disease, severe chronic obstructive pulmonary disease, severe pulmonary insufficiency, symptomatic bronchospasm).
- •A previous history of a definite neurological or psychiatric disorder, including epilepsy or dementia.
- •Evidence of active central nervous system invasion or cranial neuropathy.
- •Patients with positive hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) and peripheral blood hepatitis B virus (HBV) DNA titration assay not within the normal reference range, positive hepatitis C virus (HCV) antibody and peripheral blood HCV RNA ,positive for human immunodeficiency virus (HIV), or positive for cytomegalovirus (CMV) DNA, or positive syphilis test.
- •Subject who is allergic to the excipients of RC1012 injection or other drugs recommended in the study protocol (e.g., tolimumab, etc.).
- •Serious cardiac disease, including but not limited to severe arrhythmia, unstable angina, massive heart attack, New York Heart Association class III or IV cardiac insufficiency, refractory hypertension.
- •Persons who have previously received an organ transplant or are preparing to receive an organ transplant (except for HSCT).
- •Subject who has received other maintenance therapy drugs after HSCT or who wish to receive other maintenance therapy.
- •Subject with the presence of acute GvHD of degree III to IV or extensive chronic GvHD.
- •Active neurological autoimmune or inflammatory diseases (e.g. Guillain-Barre Syndrome (GBS), Amyotrophic lateral sclerosis (ALS)).
- •Clinically significant active cerebrovascular disease (e.g. cerebral oedema, Posterior Reversible Encephalopathy Syndrome (PRES)).
- •Subject with a life expectancy of less than 3 months.
- •Subject has been involved in other clinical studies within 3 months prior to screening.
- •Subject , in the judgement of the investigator and/or clinical criteria, is contraindicated to any study procedure or have other medical conditions that may place them at unacceptable risk.
结局指标
主要结局
Maximum Tolerated Dose (MTD)
时间窗: Up to 28 days
MTD was the highest dose for DLT in ≤1/6 subjects
Dose-Limiting Toxicity (DLT)
时间窗: Up to 28 days
To evaluate the safety, tolerability, and determine the recommended dosage of allo-DNT Cell Therapy for AML subjects after Allo-HSCT
Incidence of abnormalities
时间窗: Up to 28 days
Incidence of abnormalities in AE/SAE/laboratory tests/electrocardiograms/vital signs.
次要结局
- Pharmacokinetics (PK) indicator (T1/2)(Up to 2 years)
- Relapse-free survival (RFS)(Up to 2 years)
- 2-year overall survival(Up to 2 years)
- Pharmacokinetics (PK) indicator (Tmax)(Up to 2 years)
- Recurrence rate at 6 months(Up to 6 months)
- GvHD-free and relapse-free survival (GRFS)(Up to 2 years)
- Pharmacokinetics (PK) indicator (Cmax)(Up to 2 years)
- Pharmacokinetics (PK) indicator (AUC)(Up to 2 years)
研究者
研究点 (1)
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