NCT01567176已完成不适用
Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- Sirt6 expression in circulating leukocytes based on the aging quality
研究概览
简要总结
This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Volunteers from the SUVIMAX 2 aging cohort
- •Men and women
- •Older than 60
- •Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
- •Covered by Health Insurance System
排除标准
- •Subject not in compliance with the recommendation of French National Law
研究组 & 干预措施
Single Arm
Other
干预措施: Blood sample (Biological)
结局指标
主要结局
Sirt6 expression in circulating leukocytes based on the aging quality
时间窗: participants will be followed for the duration of the visit, an expected average of 1 day
analysis by quantitative RT-PCR method
次要结局
- Physical examination and anthropometric measurement(participants will be followed for the duration of the visit, an expected average of 1 day)
- hand and forearm muscular strength measurement(participants will be followed for the duration of the visit, an expected average of 1 day)
- Physical Activity questionnaire(participants will be followed for the duration of the visit, an expected average of 1 day)
- Cognitive assessment(participants will be followed for the duration of the visit, an expected average of 1 day)
研究者
研究点 (4)
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