The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Change in corneal thickness
研究概览
简要总结
The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is:
In patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 50 years and ≤ 90 years
- •Diagnosis of unilateral/bilateral age-related cataract
- •Nuclear grade ≥2 in LOCSIII classification
- •Scheduled for cataract phacoemulsification combined with intraocular lens implantation
- •Pupil size ≥6mm after dilation
- •Corneal endothelial cell count ≥1500 cells/mm²
排除标准
- •Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease)
- •History of ocular trauma or surgery
- •Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia)
- •Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)
研究组 & 干预措施
Phacoemulsification
干预措施: cataract surgery (Procedure)
结局指标
主要结局
Change in corneal thickness
时间窗: postoperative day 1, week 1, and month 1
Corneal thickness measured by corneal endothelial specular microscope
次要结局
- Change in corneal endothelial cell density(1 day, 1 week, and 1 month postoperatively)
- Best-corrected visual acuity(1 day, 1 week, and 1 month postoperatively)
- Intraoperative and postoperative complications(Intraoperative, 1 day, 1 week, and 1 month postoperatively)
研究者
Zitian Liu
Dr.
Zhongshan Ophthalmic Center, Sun Yat-sen University