Defining Parameters to Optimize Neurostimulation for the Treatment of Pediatric Depression
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- TMS derived measure of cortical plasticity
研究概览
简要总结
Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticity, the ability of the brain to reorganize itself and form new connections in response to stimuli. A particular class of rTMS, intermittent theta burst TMS (iTBS), is commonly used to modulate cortical excitability and induce plasticity for therapeutic purposes, notably for treatment-resistant depression.
Different iTBS stimulation parameters can be used to induce plasticity. This study will focus on two parameters, namely, the form and duration of the electromagnetic stimulation. The shape of the electromagnetic pulse refers to how the electromagnetic wave is configured over time, while the duration is simply the period during which this electromagnetic pulse remains active. These parameters are expected to influence the effectiveness of iTBS in modulating cortical activity but remain little studied.
The main aim of this study will be to compare the effectiveness of different stimulation parameters in the induction of plasticity, which will then make it possible to improve the rTMS protocols used for treatment-resistant depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be between 18 and 35 years old
- •Be of right manual dominance
- •In good health
排除标准
- •Have an implant or pacemaker,
- •Having tinnitus,
- •Have a history of fainting,
- •Have already had an epileptic seizure or have a family history of epilepsy,
- •Have a known neurological disease,
- •Be under psychotropic medication,
- •Have suffered from substance abuse or dependence in the last 6 months,
- •Have a neurostimulator,
- •Have a splinter or metallic implant in the head or the rest of the body,
- •Have a cochlear implant,
- •Have an automated injection system implanted (insulin pump),
- •Have a transdermal patch,
- •Have tattoos in the area to be studied,
- •Be pregnant or breastfeeding,
结局指标
主要结局
TMS derived measure of cortical plasticity
时间窗: Pre-iTBS, Every 5 minutes post iTBS intervention up to 60 minutes post intervention.
Change in Peak-to-peak motor evoked potential (MEP) amplitude induced by the administration of the test stimulus (stimulation intensity required to produce an MEP of 1 millivolt, approximately 120% of rMT) after iTBS
次要结局
未报告次要终点
研究者
Jean-François Lepage
Full professor, Department of Pediatrics
Université de Sherbrooke