Effect of Incentive Spirometer on Arterial Blood Gases in Liver Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Arterial blood gas (ABG) parameters
研究概览
简要总结
This study evaluated the effect of adjunctive incentive spirometer on arterial blood gases (ABGs) and early postoperative recovery in liver transplant recipients.
详细描述
In this prospective , randomized study, 40 adults undergoing living-donor liver transplantation (LT) were assigned to standard post-transplant mobilization and breathing exercises alone (n=20) or standard exercises plus structured IS training (n=20). Arterial blood gases ABG parameters (pH, PO₂, PCO₂, HCO₃-, SpO₂) were measured at baseline and on postoperative days 1-3. Linear mixed-effects models assessed group differences in ABG trajectories; slope analyses quantified decline and recovery phases. Secondary outcomes included intensive care unit (ICU) and hospital length of stay (LOS) and Post-operative pulmonary complications incidence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age between 18 and 65 years,
- •scheduled to undergo Living Donor Liver Transplant (LDLT) as recipients
- •able to understand and follow instructions for incentive spirometry use
排除标准
- •multiorgan transplantation
- •moderate-to-severe pleural effusion at baseline
- •persistent elevation in renal function tests
- •history of bleeding esophageal varices within the preceding month
- •multicentric hepatocellular carcinoma (HCC)
- •active smoking
- •decompensated cardiac disease
- •alcoholic hepatitis as the primary etiology
- •cognitive impairment or blindness precluding participation in the rehabilitation protocol.
研究组 & 干预措施
mobilization and breathing exercises alone
Patients in the control group received standard post-transplant mobilization and breathing exercises as per institutional protocol. This included early mobilization, active limb exercises, and deep breathing exercises without the use of an intensive spirometry (IS) device. The exercise regimen was initiated on the first post-operative day and continued throughout the hospital stay.
Incentive Spirometery plus standard exercises
Patients in the intervention group received structured training on Incentive spirometry (IS) use commencing on the first post-operative day. A tri-flow volumetric IS device was utilized
干预措施: Incentive Spirometry (Device)
结局指标
主要结局
Arterial blood gas (ABG) parameters
时间窗: 3 days (assessed at four time points: baseline (within 48 hours before surgery) and on post-operative days 1, 2, and 3)
Arterial pH
Arterial Blood Gas (ABG) parameters
时间窗: 3 days (assessed at four time points: baseline (within 48 hours before surgery) and at day 1, 2, and 3 post-surgery)
(3) Partial pressure of oxygen (PO2, mmHg)
Arterial Blood Gas (ABG) Parameters
时间窗: 3 days (assessed at four time points: baseline (within 48 hours before surgery) and at day 1, 2, and 3 post-surgery)
(4) bicarbonate concentration (HCO3-, mEq/L)
Arterial Blood Gas (ABG) parameters
时间窗: 3 days (assessed at four time points: baseline (within 48 hours before surgery) and at day 1,2, and 3 post-surgery)
(2) partial pressure of carbon dioxide (PCO2, mmHg)
次要结局
- length of intensive care unit (ICU) stay(Perioperative period (Hospital stay duration))
- hospital stay(Perioperative period (Hospital Stay duration))
研究者
Aya Mohammed Abdel Magid Abdel Hamid
Lecturer of Clinical Pharmacy
Cairo University