WALK - A pilot randomised controlled trial evaluating the feasibility of community walking for knee osteoarthritis

Menzies Institute for Medical Research, University of Tasmania0 个研究点目标入组 40 人开始时间: 2018年7月2日最近更新: 2020年7月6日

适应症

试验速览

暂无简介。

•1)Males and females aged 45 or over;
•2)Have clinically diagnosed knee OA (according to the American College of Rheumatology criteria);
•3)Have had symptomatic knee OA for at least 6 months with a pain visual analogue scale (VAS) score of at least 40mm/100mm over the last 7 days;
•4)Have a bone marrow lesion (BML) present on MRI (prevalence 88% at screening in our recent clinical trial).
•5)Have no difficulty in walking a city block (75-100 metres).
•6)Be willing to participate in a walking program for 6 months, and can attend on days/times of the week that scheduled walking classes are running.

•1)Severe knee pain (on standing greater than 80mm/100mm on VAS);
•2)Participation in any form of exercise at a moderate/vigorous level for >150 min/week or walking >10,000 steps/day – will be assessed for 7 consecutive days during screening using Actigraph accelerometers (meta-analysis data demonstrates that few knee OA sufferers meet these levels of activity (13% and 19% respectively));
•3)Any condition that precludes safe participation in exercise (i.e. fails the safety for exercise clearance; see below for the procedure for this);
•4)Other forms of arthritis in which disease is active and concomitant medication is used (e.g., rheumatoid arthritis);
•5)Participants who have undergone significant trauma to the ‘study’ knee in the previous 12 months (injury, arthroscopy or open surgery);
•6)Receiving intra-articular therapy (e.g. corticosteroids, hyaluronic acid) in the study knee in the last 6 months;
•7)Anticipated need for knee or hip surgery within the next 6 months;
•8)Contra-indication to MRI (for example, implanted pacemaker, metal sutures, presence of shrapnel or iron filings in the eye, claustrophobia, knee too large for scanner);
•9)Plan to commence exercise or another new treatment for knee OA in the next 6 months.
•10)Use of a gait aid.
•11)Inability to give informed consent.

发起方

Menzies Institute for Medical Research, University of Tasmania