Cardiovascular Rehabilitation in Coronary Artery Disease Patients: Influence of Different Types of Exercise Training on Selected Cardiovascular Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 试验地点
- 1
- 主要终点
- Change of flow-mediated dilatation of the brachial artery, measured in %
研究概览
简要总结
In this controlled trial, patients referred to post-myocardial infarction cardiac rehabilitation will be randomized to either interval or continuous training.
详细描述
The trial would i) compare the acute effects of each exercise type on selected cardiovascular indicators; ii) compare the chronic effects of each exercise type on selected cardiovascular indicators; iii) provide information on the association between acute and chronic effects of each exercise type; iv) provide insight into possible mechanisms of effectiveness of each exercise type; v) identify the most safe and effective exercise type for patients with coronary artery disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •myocardium infarction 120 days prior to cardiac rehabilitation
排除标准
- •contraindications for exercise training,
- •uncontrolled dysrhythmias,
- •uncontrolled heart failure (New York Heart Association (NYHA) stage IV),
- •intellectual development disorder,
- •pregnancy.
研究组 & 干预措施
Interval training group
Patients to be randomized to the 'interval training group' will have exercise training sessions 3 times per week for a period of 12 weeks. During training, they will undergo interval exercise series composed of high-intensity intervals (80-90% of peak exercise performance) and low-intensity intervals (60-70% of peak exercise performance).
干预措施: Exercise training (Other)
Continuous training group
Patients to be randomized to the 'continuous training group' will have exercise training sessions 3 times per week for a period of 12 weeks. During training, they will undergo moderate continuous exercise training at 75% of peak exercise performance.
干预措施: Exercise training (Other)
结局指标
主要结局
Change of flow-mediated dilatation of the brachial artery, measured in %
时间窗: 3 months
次要结局
- Change in total cholesterol, LDL, HDL, triglycerides and glucose levels, measured in mmol/l(3 months)
- Change in overall haemostatic potential(3 months)
- Change in insuline level, measure in microIU/ml(3 months)
- Change of the arterial stiffness coefficient(3 months)
- Change of maximal oxygen uptake during exercise, measured in ml/kg/min(3 months)
- Change in IL-6, IL-8, IL-10, TNF-alpha and NT-proBNP levels, measured in ng/l(3 months)
- Change in osteopontin and D-dimer levels, measured in microg/l(3 months)
- Change in fibrinogen and Lp(a) levels, measured in mg/dl(3 months)
- Change in selectin and hsCRP, measured in mg/l(3 months)
- Change in hsTnI, CK MB, endocan, sST2, galectin-3, NGAL, CD40 ligand and BDNF, measured in ng/l(3 months)
- Change in copeptin levels, measured in pmol/l(3 months)
- Change of the heart rate variability(3 months)
- Change of the heart rate recovery(3 months)
- Change in health-related quality of life using SF-36 questionnaire, measured in points(3 months)
- Change in MR-proADM and MR-proANP, measured in nmol/l(3 months)
- Change in homoarginine, ADMA and SDMA levels, measured in micromol/l(3 months)
研究者
Borut Jug
Associate Professor
University Medical Centre Ljubljana