The Effect of Glucomannan Powder on Improving Gut Microbiota.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- gut microbiota
研究概览
简要总结
The object of this study is evaluating the effects of the Glucommanan on the healthy human subjects who are. In this trial, at most 30 healthy subjects whose ages are 20~65 years old (15 for placebo and 15 for intervention)will be included. The total experiment will be 9 weeks and the intervention period will be 6 weeks, within which, at week 0, 6, and 7, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST, also known as GOT), alanine aminotransferase (ALT, also known as GPT), blood urea nitrogen (BUN), serum creatinine (Cr), fasting blood glucose (Glucose, AC) and adiponectin would be measured. Feces samples and anthropometric data will also be acquired. The results will be analyzed according to the methods published by the Ministry of Health and Welfare of Taiwan Food and Drug Administration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Both genders, aged between 20 and 65 years.
- •No history of gastrointestinal disorders or other significant health issues.
- •Overall good health.
排除标准
- •- Participants who have taken antibiotics or any medications/supplements that could affect the gut microbiota within 1 week prior to the experiment or during the study.
- •Pregnant or breastfeeding women.
- •Smokers or individuals with excessive alcohol consumption.
- •Chronic disease medication usage for less than 3 months.
- •Postmenopausal women on hormone replacement therapy.
- •Individuals with acute illnesses such as a cold.
研究组 & 干预措施
Placebo group
2 packs of corn starch daily
干预措施: Placebo (Dietary Supplement)
Intervention group
2 packs of glucomannan powder daily
干预措施: Glucomannan (Dietary Supplement)
结局指标
主要结局
gut microbiota
时间窗: Week(0) (Baseline), Wk(6),Wk7
Evaluation of Gut Microbiota by Analysis of Four Indicator Strains and 16S rRNA Sequencing Using Fecal Samples
次要结局
未报告次要终点